A new study out of Columbia University says the Omicron variant is “markedly resistant” to vaccines and boosters might not do much to help, spelling bad news for the country as Omicron spreads and COVID-19 cases rise nationally. The Omicron variant was first detected in South Africa in November and is widely believed to soon become the dominant strain in the US, eclipsing the Delta variant. The scientists express concern in the study published Wednesday that the variant’s “extensive” mutations can “greatly compromise” the vaccine, even neutralizing it. “Even a third booster shot may not adequately protect against Omicron infection,” the study said, adding it’s still smart to get a booster. The new Columbia study ends with a grave warning and a call to action to the scientific community.