Blood samples were taken monthly from one to six months post infection to examine different elements of the immune response. The preprint report posted on Research Square details a highly complex and variable immune response following COVID-19 infection. Dr Christina Dold of the Oxford Vaccine Group and study author said: ‘Our study is one of the most comprehensive accounts of the immune response following COVID-19 in both symptomatic and asymptomatic individuals. While the majority of people who had symptomatic disease did have measurable immune responses at six months post infection, a significant minority (17/66; 26%) did not. The vast majority of people who experienced asymptomatic disease (11/12; 92%) did not exhibit a measurable immune response at six months post infection.