This breakthrough will improve understanding of how differences in DNA sequences can lead to increased risks of developing many different diseases. This is the equivalent of being able to measure contacts in the DNA fibre that are 1km apart to the nearest millimetre. For example, at the moment we know that there is a genetic variant which doubles the risk of being severely affected by COVID-19. However, we do not know how the genetic variant makes people more vulnerable to COVID-19. 'This new breakthrough is helping us to work out how this causes severe COVID and which genes are involved.