Colwell said on average about 10 to 15 people who've taken fentanyl are treated in the San Francisco General emergency room a day, sometimes more. Naloxone (Narcan) is a medicine used treat a fentanyl overdose and prevent death, and when administered, patients actively vomit and sweat. ---Amid a drug epidemic fueled by fentanyl, 2021 is on track to be a record-breaking year for overdose deaths in San Francisco. In January through April, 252 people died from overdoses, according to preliminary data from the San Francisco Chief Medical Examiner's Office. "Fentanyl has become the dominant opioid on the street in San Francisco," said Coffin.