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The Department of Chemistry and Molecular Biology conducts high-quality research and education in chemical sciences and molecular life sciences. Our research and education focus is on a deep understanding of chemical and biological processes in cells and in the environment.
We address important societal issues such as antibiotic resistance, cancer, brain diseases, environmental problems and climate change. In this way, we contribute to achieving the UN's global goals for sustainable development in the areas of good health and well-being, sustainable energy for all, sustainable cities and communities, and combating climate change.
The department is an international environment with interdisciplinary collaborations in both research and education, and contributes strongly to the University of Gothenburg's top ranking in life science.
The department is responsible for postgraduate education in the subject area Natural Sciences with a focus on chemistry, biophysics, biology and educational science. In addition, the department hosts educational programs in molecular biology, genomics and systems biology, chemistry, organic chemistry and pharmaceutical chemistry, as well as prescription education. The department collaborates with various societal actors such as schools, business and authorities. The Department of Chemistry and Molecular Biology has around 200 employees. We are located on Campus Medicinareberget in Gothenburg.
Neutze has been working in the field of time-resolved serial X-ray crystallography of integral membrane proteins using X-ray free electron lasers since 2010. Both time-resolved serial crystallography and serial crystallography using synchrotron radiation later emerged as powerful experimental methods for studying protein structure and function. There are many challenges associated with the processing of serial X-ray crystallography data and in extracting high quality electron density maps. There have also recently been major commitments made towards time-resolved serial crystallography by synchrotron radiation sources, including the construction of new beamlines at MAX IV Laboratory, the ESRF, Diamond and the Swiss Light Source.
Several years ago, Neutze's group recorded time-resolved serial synchrotron X-ray crystallography data from microcrystals of sensory rhodopsin II and sensory rhodopsin II in complex with its transducer protein. These data were collected at the Swiss Light Source. Since these crystals only diffracted to relatively low-resolution, we must improve the analysis of these data by utilizing recent advances in X-ray data processing tools. Most importantly, there have been critical advances in the use of machine learning for the processing and scaling of serial X-ray crystallography data (eg. Careless: https: // www. nature.com/articles/s41467-022-35280-8) as well as the development and release of other tools for analyzing time-resolved X-ray crystallography data (eg. Xtrapol8: https: // www. nature.com/articles/s42003-022-03575-7).
We therefore seek to fill position as Researcher focused upon the analysis of serial synchrotron X-ray crystallography data collected from sensory rhodopsin II, and sensory rhodopsin II in complex with its transducer protein. The goal for this position is to bring the serial crystallography work on sensory rhodopsin II to publication. The successful candidate must be able demonstrate expertise in the processing of serial crystallography data, as well as experience in the use of machine learning tools for the analysis of these data. Since complementary spectroscopy studies from crystals of sensory rhodopsin will be required for publication, a working knowledge of the sensory rhodopsin II and transducer protein production, purification and crystallization protocols, is also essential.
DutiesTo bring serial synchrotron crystallography data collected from sensory rhodopsin II to publication we are seeking to appoint a Researcher for twelve months who has can:
For the position of Researcher, applicants must have completed a PhD degree in Natural Science or its equivalent. It is also essential that the successful candidate can demonstrate practical knowledge of:
Applicants must be willing to participate in all other tasks required for the publication of time-resolved serial crystallography data from sensory rhodopsin II.
The quality of the publication record of the applicant concerning the study of conformational changes in proteins other than sensory rhodopsin II will be an important consideration. Contributions to unpublished manuscripts in PhD thesis will also be considered a merit.
EmploymentFixed term during 12 months full time (100%) at the Department of Chemistry and Molecular Biology.
Contact information for the postIf you have any questions about the position, please contact Richard Neutze ([email protected])
UnionsUnion representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
ApplicationTo apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg's recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
The application must include:
Applications must be received by: 2024-04-19
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
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