Researcher In Neurochemistry

The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

At the Institute of Neuroscience and Physiology, at the Sahlgrenska Academy, we conduct research and education covering a wide range of knowledge areas. The institute comprises five different departments: Clinical Neuroscience, Health and Rehabilitation, Pharmacology, Physiology and Psychiatry and Neurochemistry.

The Institute of Neuroscience and Physiology invites applications for a Researcher in Neurochemistry position at the Department of Psychiatry and Neurochemistry.

The Department of Psychiatry and Neurochemistry provides world leading translational research spanning cell and animal models to clinical studies and extensive epidemiological studies. Here, ground breaking research in areas such as bipolar disorder, addiction medicine, aging, neurochemistry and psychiatry are conducted.

Current efforts of dealing with Alzheimer's disease (AD) pose an immense societal challenge, particularly as there are still no curative treatments as the pathogenic mechanisms of AD are not understood. The major hallmark of AD is the progressive accumulation of Aβ and hyperphosphorylated-tau protein, into intra- and extracellular deposits. Although Aβ has been suggested to be a critical inducer of seeding neurotoxic plaque and tangle pathology, the exact mechanisms underlying Aβ plaque pathology remain elusive. It is therefore critical to elucidate how Aβ is aggregating at the single cell level.

The major goal of this project is to develop and apply novel chemical imaging tools based on photoactive fluorescent tracers to study biochemical changes in brain tissue from both in genetic mouse models of AD as well as in Alzheimer patients. The goal is to understand where, when and how Aβ peptides aggregate over time and build different plaque structures and cause neurotoxic effects downstream.

We are looking for a positive, driven and independent research fellow with solid experience in genetic models of Alzheimer's Disease pathology and tissue and cellular analysis using immunohistochemistry.

When assessing the applicants' qualifications, great importance will be attached to research experience focusing on method development and knowledge regarding spectroscopy, organic synthesis of photoactive compounds and characterization of their spectroscopic properties in vitro and in situ of as well as tissue analysis and fluorescence microscopy. This should be documented through publications in international scientific journals with peer-review systems.

The candidate must demonstrate very good knowledge in English (speech and writing). Furthermore, good ability to independently process data and write scientific publications is a prerequisite as well as being otherwise flexible and able to work both in groups and independently. Great importance will be attached to personal suitability.

The employment is limited (temporary) for 6 months, 100% of full-time, and is placed at the Institute of Neuroscience and Physiology. Starting date: as soon as possible or as agreed.

If you have questions regarding the employment please contact Associate Professor Jörg Hanrieder, phone: +46 343 23 77, e-mail: [email protected]

Manager in charge is Professor/Head of Department Henrik Zetterberg, phone: +46 768 672 647, e-mail: [email protected]

Application documents are not to be submitted through the contact persons.

Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/en/work-at-the-university-of-gothenburg/how-to-apply

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Please enclose PhD certificate with the application.

Applications must be received by: 2024-06-10

Information for International Applicants

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The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.