Come to CEITEC MU in Brno and join us!
We are passionate molecular biologists at CEITEC looking for
Postdoctoral Researcher
in Lymphoid Microenvironment Models And Their Use To Study Targeted Therapy And Resistance In B Cell Malignancies
About this position:
You will work in a team of young investigators that challenge major problems in the field of hematology. We do basic and translational science, but with the objective to help patients in the future (we have access to primary samples with hem. malignancies, and mouse models).
Chronic lymphocytic leukemia (CLL) cells and indolent lymphomas rely on microenvironmental signals for survival, proliferation, and therapy resistance. CLL cells undergo apoptosis in vitro, necessitating microenvironment models for long-term culture and proliferation studies. Existing in vitro and in vivo models, based on coculture with T-lymphocytes or stromal cells, mimic some aspects of the natural microenvironment but have limitations.
This research aims to develop and optimize models replicating the lymphoid microenvironment to study new therapeutic strategies, including drugs targeting CLL proliferation, resistance mechanisms, and combinatory approaches not feasible in conventional cultures. A recently developed co-culture model enables robust CLL cell proliferation. Using primary patient samples and cell lines, the project will employ functional assays, RNA sequencing, genome editing, and drug screening to explore microenvironmental dependencies and resistance to targeted therapies.
The candidate profile:
What you will learn and do:
What we provide to you:
How to apply?
Application deadline: 15.1.2025
Start date: early 2025 (to be negotiated)
Contact the PI and submit a CV by email to: [email protected]