Come to CEITEC MU in Brno and join us!
We are passionate molecular biologists at CEITEC looking for
Postdoctoral Researcher
in Long Non-coding RNAs (lncRNAs) in Microenvironmental Interactions of B Cell Chronic Lymphocytic Leukemia
About this position:
You will work in a team of young investigators that challenge major problems in the field of hematology. We do basic and translational science, but with the objective to help patients in the future (we have access to primary samples with hem. malignancies, and mouse models).
Our research group focuses on non-coding RNAs and microenvironmental interactions of malignant B cells, supported by an ERC Starting grant (2019–2024) and GACR EXPRO (2025-2029). We identified novel regulators, including microRNAs critical for B cell functions, but the role of long non- coding RNAs (lncRNAs) remains unclear. Our goal is to explore lncRNAs in B cell receptor (BCR) signaling and B-T cell interactions, with a focus on chronic lymphocytic leukemia (CLL), driven by BCR pathway and B-T cell abnormalities. These insights are relevant for other B cell malignancies, autoimmune diseases, and normal B cells.
We identified three candidate lncRNAs involved in CLL microenvironmental interactions. Using biochemical and cellular approaches, CRISPR interference, RNA pulldown, and a novel lncRNA knockout mouse model, we will study their molecular functions. One knockout mouse model is complete, and its phenotype will be analyzed alongside breeding with Eu-TCL1 CLL models. Primary patient samples will provide complementary data.
Additionally, we developed a co-culture model enabling robust CLL cell proliferation (~50%) in vitro, allowing the first CRISPR screening of lncRNAs regulating CLL cell growth. This groundbreaking approach will improve understanding of CLL biology and identify potential therapeutic targets.
The candidate profile:
What you will learn and do:
What we provide to you:
How to apply?
Application deadline: 15.1.2025
Start date: early 2025 (to be negotiated)
Contact the PI and submit a CV by email to: [email protected]