Osteoarthritis (OA) is a complex disease in which multiple tissues in the joint are affected. Recently, multiple OA risk genes were identified based on small genetic variations (SNPs) in the regulatory sequences of these genes. These variations can lead to unfavorable expression of these genes contributing to disease progression. OA patients have different unique combinations of SNPs that lead to OA onset and progression. In this project we will uncover the integrated effects of deviant OA risk gene expression in cartilage with the aim to develop effective disease-modifying therapies. As a PhD student, you will play a central role in this process by building an in silico disease map that models these effects and enables more precise treatments.
You will be part of the multidisciplinary research group of dr. Janine Post, who specializes in quantitative biology and computational approaches to understanding cell fate and is part of the Department of Bioengineering Technologies. This work will be performed in collaboration with prof. dr. Ingrid Meulenbelt of the LUMC, an expert in OA pathophysiology and molecular epidemiology, whose work has significantly advanced our understanding of OA genetics and its clinical implications.
Your profileYou are a highly motivated researcher who is driven by curiosity, and you have:
For inquiries about this position and our offer you can contact Dr. Janine Post ([email protected]). An application for this position should be accompanied by:
The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.
Want to know more? Post, J.N. (Janine)Associate Professor
Post, J.N. (Janine)Associate Professor
Do you have questions about this vacancy? Then you can contact Janine for all substantive questions about this position and the application procedure. For general questions about working for the UT, please refer to the chatbot.
ContactPhone:+31534894205
Email:[email protected]
How to apply Step 1Apply. When you see a vacancy that appeals to you, you can apply online. We ask you to upload a CV and motivation letter and/or list of publications. You will receive a confirmation of receipt by e-mail.
Step 2Selection. The selection committee will review your application and you will receive a response within 2 weeks after the vacancy has been closed.
Step 31st interview. The 1st (online or in person) meeting serves as an introduction where we introduce ourselves to you and you to us. You may be asked to give a short presentation. This will be further explained in the invitation.
Step 42nd interview. In the second interview, we will further discuss the job content, your skills and your talents.
Step 5The offer. If the conversations are positive, you will be made a suitable offer. If applicable, we will sign you up for screening.
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