Associate Researcher In Structural Modeling

Göteborg University
March 21, 2024
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Fixed term during si
Working Time:Full time
Working type:N/A
Ref info:N/A

The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Department of Chemistry and Molecular Biology conducts high-quality research and education in chemical sciences and molecular life sciences. Our research and education focus on a deep understanding of chemical and biological processes in cells and in the environment.

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The department is responsible for postgraduate education in the subject area Natural Sciences with a focus on chemistry, biophysics, biology and educational science. In addition, the department hosts educational programs in molecular biology, genomics and systems biology, chemistry, organic chemistry and pharmaceutical chemistry, as well as prescription education. The department collaborates with various societal actors such as schools, business and authorities. The Department of Chemistry and Molecular Biology has around 200 employees. We are located in central premises on Campus Medicinareberget in Gothenburg

Neutze has been working in the field of time-resolved X-ray scattering studies of integral membrane proteins since 2008. Because X-ray scattering data are not as information rich as X-ray diffraction data, structural modelling is challenging. This problem is even more acute when working with integral membrane proteins since one must model both the membrane protein and the surrounding detergent micelle. Several years ago we recorded time-resolved X-ray solution scattering data from samples of detergent solubilized cytochrome c oxidase. We have good quality data from these experiments at the European Synchrotron Radiation Facility (ESRF) but we must fit these data with a structural model to allow this work to be published. The ERC grant Proton Pump will close on December 31, 2024, and we therefore need to complete this modeling in the near future. With this goal in mind, we are advertising a six-month position as Associate Researcher to focus on modeling conformational changes in cytochrome c oxidase for fitting against time-resolved X-ray solution scattering data. The successful candidate must demonstrate expertise in structural modelling of integral membrane proteins using the molecular dynamics simulations package Gromacs, and applying these simulations to fit X-ray solution scattering data.


Time-resolved X-ray scattering data that has been collected at the ESRF must be analyzed and modelled. This position aims to model time-dependent changes in X-ray solution scattering data collected from samples of cytochrome c oxidase. In our experiments using synchrotron radiation, a laser pulse was used to release molecular oxygen from a light sensitive compound, and this oxygen would react with reduced samples of cytochrome c oxidase in solution. X-ray scattering data were then recorded from these samples as a function of the time-delay between the laser pulse that initiated the reaction, and the X-ray pulse which probed the protein's structure. To model the experimental changes in X-ray scattering using structural changes, the successful candidate will run simulations of cytochrome c oxidase using the molecular dynamics package Gromacs, and will predict X-ray scattering changes using the package Crysol. The successful candidate must also be able to work with MatLab to combine their structural results and X-ray scattering predictions with the best fits to the X-ray scattering data. Because there is no time for training, the successful candidate must demonstrate that they can work with the ba3-cytochrome c oxidase in Gromacs, and must also be familiar with how molecular dynamics simulations and used to fit time-resolved X-ray solution scattering data. The overriding task is to bring the analysis of our time- resolved X-ray scattering data to a level where scientific conclusions can be drawn and the work published.


The successful candidate must have a master of science degree in chemistry, molecular biology, structural biology or its equivalent. The successful candidate must also have several years of working experience in the analysis of X-ray scattering data recorded using synchrotron radiation. The successful candidate must also have a practical knowledge of the programming languages MatLab and Python and be able to build and run simulations of cytochrome c oxidase in the molecular dynamics package Gromacs.

Experience in presenting results from X-ray scattering studies (eg. in publications or a PhD thesis) is a merit.


Fixed term during six months full time (100%) at the Department of Chemistry and Molecular Biology.

Contact information for the post

If you have any questions about the position, please contact Richard Neutze ([email protected]).


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You must include the following, in PDF format

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  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
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  • Applications must be received by: 2024-03-21

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