To evaluate the impact of the COVID-19 Omicron variant on maternal and neonatal outcomes the researchers studied 1,545 pregnant women diagnosed with the variant and 3,073 non-diagnosed, concomitant pregnant women as controls. COVID-19 Omicron variant during pregnancy was associated with increased risks of maternal morbidity, severe pregnancy complications, and hospital admission, especially among symptomatic and unvaccinated women. Prevention of severe COVID-19 symptoms and complications requires women to be completely vaccinated, preferably with a booster dose as well. Of concern is that severe symptoms of the disease occurred in 4% to 7% of unvaccinated women diagnosed with the COVID-19 Omicron variant during pregnancy. As it is impossible to predict who will develop severe symptoms or complications, universal complete vaccination is required.