Research Fellow in In-Vivo Protein Folding

University of Southampton
May 27, 2024
Offerd Salary:£34,980 to £42,978
Working address:N/A
Contract Type:Fixed Term Closing D
Working Time:Full time
Working type:N/A
Ref info:N/A
Research Fellow in In-Vivo Protein Folding School of Biological Sciences

Location: Highfield Campus Salary: £34,980 to £42,978 per annum Full Time Fixed Term Closing Date: Monday 27 May 2024 Interview Date: To be confirmed Reference: 2703824BJ

We are looking for a motivated Post-Doctoral Research Fellow to work with Amrit Mudher and Phil Williamson developing methods to investigate how the cellular milieu influences the folding, structure and function of large molecular complexes including amyloid fibre structure and integral membrane proteins. This Leverhulme Trust funded project will combine the powerful genetic tractability of Drosophila melanogaster with the molecular resolving power of modern sensitive solid-state NMR experiments to report on the structure, dynamics, and function of these assemblies in-vivo.

The project will build on preliminary studies that have demonstrated that modern proton detected ultra-high field solid-state NMR methods can provide the necessary resolution and sensitivity to study the structure and dynamics of large molecular complexes in-situ in the model organism Drosophila melanogaster. The project seeks to establish workflow that will enable the induced expression and labelling of macromolecular complexes and a range of NMR methodologies that permit the characterization of their structure and dynamics as well as interactions with other cellular components.

Ideally applicants should possess a PhD in biochemistry (or related descipline) and ideally experience in either Drosophila research and/or solid-state NMR. The position will be based in the School of Biolgical Sciences, which provides state of the art facilities for invertebrate research and solid-state NMR research (both locally and through the UK National Research Facility). To discuss the position, please don't hesitate to contact Prof Amrit Mudher ([email protected]) or Prof Phil Williamson ([email protected]).

Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.

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    Apply by midnight on the closing date. For assistance contact Recruitment on +44(0)2380 592750 or [email protected] quoting the job number.


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