Come to CEITEC MU in Brno and join us!
We are passionate molecular biologists at CEITEC looking for
Postdoctoral Researcher
in Role Of Transcription Factors In Onset And Progression Of B-Cell
Malignancies
About this position:
You will work in a team of young investigators that challenge major problems
in the field of hematology. We do basic and translational science, but with
the objective to help patients in the future (we have access to primary
samples with hem. malignancies, and mouse models).
Transcription factors (TFs) regulate cell growth, development, and
hematopoietic differentiation. Disruption of transcription mechanisms can lead
to blood cell malignancies, including chronic lymphocytic leukemia (CLL) and
other B-cell cancers. Abnormal TF function, caused by dysregulation or genomic
aberrations, often activates oncogenes through deregulated chromatin
structures and altered enhancer/promoter activity in CLL. Post-translational
modifications of TFs due to leukemia microenvironment signaling also
contribute to disease progression.
This project explores the role of candidate TFs in B-cell malignancies,
focusing on CLL, and evaluates targeted therapies using TF inhibitors or
chromatin regulators. Several TFs potentially regulate B-cell survival,
proliferation, and immune crosstalk. The PhD student will study these using
genome editing (CRISPR), RNA sequencing, primary samples, and in vitro/in
vivo mouse models, with implications for understanding therapy resistance.
The candidate profile:
Motivated smart person with "drive" to work independently, but also
willing to learn from other people in the lab and collaborate
Having degree in Molecular biology, Biochemistry, or similar field and
have deep interest in molecular biology and cancer cell biology
What you will learn and do:
Think and work independently as a scientist, design experiments and
formulate hypothesis
Write of abstracts and papers (and course in grant writing and
presentation of data)
Attend conferences to present your research
Spend 1-2 months visit(s) in collaborating labs in Europe or US
Collaborate with experts in wet lab research and bioinformatics
Critically analyze scientific data (regular journal clubs)
Classical and novel methods of molecular biology (e.g. RNAseq, Crispr,
Cut&Tag, mouse mdoels, immunoblotting, flow cytometry, qRT-PCR, cell
cultures, cloning), and you will use our in vitro models for
microenvironmental interactions, and artificial activation/inhibition
signalling pathways to decipher the gene regulatory loops
Supervise students, if interested
What we provide to you:
Open access to CEITEC MU core facilities with state-of-the-art equipment
and experienced staff
Full contract for Post-Docs with competitive salary (funded by ERC
grant)
Flexible working hours
Support for further education and professional development
Benefits package: 6 weeks of paid holiday, medical insurance, financial
contribution to meal and kindergarten/pension scheme, Multisport card,
mental health care, sports at the campus
Kindergarten Elánek in Campus
Support in these areas:
Welcome Office service before and after arrival
Grant Office support
Postdoc Peer Committee
CEITEC events – workshops, conferences, lectures, training, family gathering etc.
More at Why work at CEITEC MU?
How to apply?
Application deadline: 15.1.2025
Start date: early 2025 (to be negotiated)
Contact the PI and submit a CV by email to: [email protected]
