Department
Mathematics
Salary
£36,024 - £44,263 per year
Grade
Grade 6
Contract status
Fixed term
Hours of work
Full-time
Based at
University of York campus
Interview date
30/10/2024
Posted Date
06/09/2024
Apply by
04/10/2024
Job Reference
13547
Documents
Are you curious about how viruses form, evolve and infect their hosts? We are looking for a Postdoctoral Research Associate with expertise in Mathematical Biology or Computational Biophysics to develop models of virus structure, viral evolution, and mechanisms in viral life cycles based on experimental data. In collaboration with the Stockley lab in Leeds, we discovered a code embedded within the genetic code of human viruses that promotes efficient formation of viral particles. This code relies on multiple dispersed sequence/structure motifs in the viral genome. Your computational modelling will enable us to study the mechanisms by which this code promotes virion formation, orchestrates different stages of the viral life cycle, and imposes constraints on viral evolution. In particular, dynamic changes of this code during a viral life cycle destabilise the protective viral protein shell and thus facilitate the timely release of the viral genome. Your modelling will study this interplay between capsid stability and genome organisation, contributing to its exploitation in drug/gene delivery, therapy and vaccination.
This position is funded by the Wellcome Trust and is fixed term for 3 years. You will join the interdisciplinary team of Professor Reidun Twarock (York/theory, where this post will be based) and Professor Peter Stockley (Leeds/experiment) and contribute to the production of high-quality research papers, as well as assist with the dissemination of the research. We offer excellent career prospects and mentoring, which makes this an ideal springboard for an ambitious scientist with career aspirations in academia or industry.
Requirement:
For enquiries, please contact Prof Reidun Twarock ([email protected]; please use subject line “post-doc-October2024” and include a curriculum vitae).
The University strives to be diverse and inclusive – a place where we can ALL be ourselves.
We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork