Applications are invited for a Postdoctoral Research Associate in the lab of Dr. Heather Machado in the Department of Pathology, University of Cambridge. The Machado Lab is interested in how tumour and immune cells co-evolve and contribute to cancer progression. Methods of evolutionary genetics and multiomic datasets are used to study key questions in cancer immunology, such as the timing of the immune response to cancer, the role of inflammation on remodeling the immune response to cancer and the somatic evolution of the immune response to immunotherapy.
The Machado Lab is looking for a Computational Biologist/Genomicist to leverage single-cell genomic and transcriptomic datasets to understand the somatic evolution of the T cell response to cancer. The successful applicant should:
Hold a relevant PhD Qualification
Experience in analysing genomic and/or multiomic datasets
Excellent oral and written communication skills
Able to manage time effectively
Good at working independently
Enthusiastic to interact with colleagues in a multi-disciplinary and collaborative environment
Please see further information document for further details.
Standard components of the genomic data analysis include variant calling, artifact filtering, mutational signature analysis, phylogenetic tree building, mutational timing estimation and selection analysis.
We are particularly excited about recent technological advancements in single- cell whole genome sequencing, such as primary template-directed amplification (PTA), which substantially expands the scope of answerable somatic evolution questions.
For more information regarding the research of the laboratory, please see https:// www. machado-lab.org/.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
We welcome applications from individuals who wish to be considered for part- time working or other flexible working arrangements.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal queries regarding the research of the laboratory and the role should be directed to Dr Heather Machado, [email protected].
Please quote reference PK43661 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further informationDepartment of Pathology, Central Cambridge
Salary£36,024-£44,263
ReferencePK43661
CategoryResearch
Published21 October 2024
Closing date1 December 2024