Deadline
Apr 07, 2027
Closing in 170 days
Location
N/A
United States
Employment
Fixed contract (1-4 years)
Full time
Reference
N/A
Posted
Oct 09, 2026
About the role
Academic Careers at IU
Postdoctoral Fellow in Functional Genomics and Human Disease Mechanisms
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Posting Details
Position Details| Title | Postdoctoral Fellow in Functional Genomics and Human Disease Mechanisms |
|---|---|
| Specific Title | |
| Appointment Type | Postdoctoral Fellow |
| Department | IUSM - Medical & Molecular Genetics |
| Campus | IU School of Medicine Indianapolis |
| Position Summary | The Department of Medical and Molecular Genetics at Indiana University School of Medicine is seeking a highly motivated and creative Postdoctoral Fellow in Functional Genomics and Human Disease Mechanisms to join the Azaiez-Booth Laboratory in Indianapolis, Indiana. Our laboratory uses human genetics and functional genomics to understand how disruption of genes, transcripts, and regulatory elements produces human disease. A central goal of the laboratory is to move beyond genetic association or variant annotation to experimentally determine the molecular and cellular consequences of disease-associated genomic variation. The successful candidate will lead mechanistic studies investigating genes and regulatory loci implicated through human genomic analyses. One major area of investigation involves long noncoding RNAs and regulatory genomic regions disrupted by structural variation, although the position is intentionally broader than lncRNA biology. The fellow will have opportunities to pursue diverse projects in which human genetic discoveries create compelling biological questions that require experimental investigation. This position is particularly well suited for a scientist interested in mechanistic biology, developmental or cellular genetics, and translating human genomic findings into experimentally testable models. Research Opportunities Projects may include: · Functional characterization of disease-associated genes, noncoding transcripts, and regulatory elements.· Investigation of structural variants that alter gene regulation or disrupt noncoding genomic loci.· Development of cellular models for studying candidate disease mechanisms.· CRISPR/Cas-mediated genetic perturbation and genome engineering.· Gene-expression and regulatory studies.· Transcriptomic and other genomic approaches for defining downstream consequences of genetic perturbation.· Mechanistic investigation of genes emerging from human gene-discovery studies.· Functional follow-up of candidate disease genes requiring additional experimental evidence.· Integration of molecular and cellular findings with human genetic and phenotypic data. A particular strength of this position will be the opportunity to work across both deep mechanistic projects and focused functional studies arising from ongoing gene-discovery efforts. This structure allows the fellow to develop a major hypothesis-driven research direction while also contributing to shorter, high-value projects that can rapidly generate biological insight. This work will include in vivo studies using mouse models along with cell- and molecular-based assays. Prior animal research experience is preferred but not required; however, candidates must be willing to work with mice and to learn the animal-handling and experimental procedures necessary for their projects. Training and Career Development Postdoctoral fellows will receive close mentorship while being encouraged to develop increasing scientific independence. Training will emphasize formulation of research questions, rigorous experimental design, manuscript preparation, scientific presentation, fellowship and grant writing, mentoring of junior researchers, and development of an independent research program. The fellow will have opportunities to collaborate broadly with investigators in human genetics, clinical genetics, genomics, molecular biology, and related disciplines across Indiana University School of Medicine and collaborating institutions. We especially encourage applicants who want to build a research career connecting human genomic discovery with experimental disease biology. Fellows will be supported in developing independent questions and preliminary data that can form the basis for future fellowship, career-development, and independent research applications. IU School of Medicine is committed to being a welcoming campus community, and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for students, staff, and faculty. We invite individuals who will join us in our mission to improve health and well-being throughout the state of Indiana. Department Contact for Questions Applicants should submit:
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| Basic Qualifications | QualificationsApplicants must have a Ph.D. or equivalent doctoral degree in genetics, molecular biology, developmental biology, cell biology, genomics, neuroscience, biomedical sciences, or a related field by the start of the appointment. We are particularly interested in candidates with experience in one or more of the following areas: · Functional genetics or functional genomics.· Mammalian cell culture.· CRISPR/Cas genome editing.· Developmental or cellular disease models.· RNA biology.· Gene-expression or transcriptional regulation.· Noncoding RNA or regulatory genomics.· Structural variation.· Transcriptomics or other sequencing-based approaches.· Molecular cloning and biochemical assays. Expertise specifically in lncRNA biology is not required. Candidates with a strong background in experimental genetics or molecular and cellular biology who are interested in applying their expertise to human disease mechanisms are strongly encouraged to apply. The ideal candidate will be intellectually curious, experimentally rigorous, and comfortable moving between genetic observations and mechanistic questions. The ability to independently design experiments, interpret complex results, troubleshoot experimental systems, and communicate findings clearly will be important for success. |
| Department Contact for Questions | Questions regarding the position and application materials may be directed to: Dr. Hela Azaiez, PhD ([email protected]) and Dr. Kevin T.A. Booth PhD, FACMG ([email protected]). |
| Additional Qualifications | |
| Special Instructions | |
| Priority Application Review Deadline | |
| Expected Start Date | |
| Posting Number | IUSM-02534-2026 |
Supplemental Questions
Required fields are indicated with an asterisk (*).
- *
How did you hear about this position?
- Personal Contact: At Professional Meeting or Conference
- Personal Contact: Direct Contact by Search Committee
- Personal Contact: Referred by colleague or advisor
- Personal Contact: School of Medicine recruiter
- Personal Contact: IUHP Physician Recruiter
- Announcement: Other Journal or Magazine
- Announcement: Other Website
- *
Are you a dual career partner (your partner or spouse is already being recruited)?
- Yes
- No
- *
Have you previously been employed with IU?
- Yes
- No
Applicant Documents
Required Documents- Curriculum Vitae
- Letter of Application
- List Of References
How to apply
Read the full posting, then apply through the employer's own site. Applications are handled by the institution, not by AcademicGates.
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