Working with organoid models to understand mechanisms in familial interstitial lung disease
Dr Dickens and the Marciniak Group are seeking a postdoctoral fellow to drive innovation in a programme of research investigating triggers of alveolar epithelial dysfunction in familial forms of interstitial lung disease. You will work with novel alveolar organoids, creating patient-specific models which you will interrogate using innovative culture techniques, genetic manipulation and multi-omics analysis including proteomics and transcriptomics with a view to identifying novel therapeutic targets.
You should have a track record in wet-lab cell biology and possess a PhD in a relevant discipline. Prior experience of working with organoids and/or in respiratory disease research would be an advantage, but training will be provided.
The successful applicant will join Dr Dickens, a clinician scientist, and a diverse team of basic and translational scientists and clinicians within the Marciniak Group. We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.
Fixed-term: The post will run for 3 years in the first instance.
Recent relevant papers
Lim K, Rutherford EN, Sun D, Van den Boomen DJH, Edgar JR, Bang J, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. BioRxiv (https: // doi.org/10.1101/2023.08.30.555522)
Dickens JA, Rutherford EN, Abreu S, Chambers JE, Ellis MO, van Schadewijk A, Hiemstra P, Marciniak SJ. Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. Eur Respir J 2022;59:2100267
Please contact Dr Jenny Dickens at [email protected] for further information.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applicants must have (or be close to obtaining) a PhD.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SC42003 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further informationC.I.M.R. Medicine
Salary£36,024-£44,263
ReferenceSC42003
CategoryResearch
Published9 June 2024
Closing date3 July 2024