Unraveling Structure - Membranotropic Relationships By Use Of Constrained Viral Fusion

9 Oct 2023

Job Information

Organisation/Company

CY Cergy Paris University

Department

Chemistry

Research Field

Chemistry » Organic chemistry

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

14 Dec 2023 - 13:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

2 Sep 2024

Is the job funded through the EU Research Framework Programme?

H2020 / Marie Skłodowska-Curie Actions COFUND

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We are looking for a candidate to submit a proposal to EUtopia-SIF for a postdoctoral position (https: // eutopia-university.eu/english- version/opportunities/research/eu…)

This proposal concerns the improvement of the membranotropic properties of hydrophobic fusion peptides. These are capable of interacting with membranes through numerous interactions. Such interactions require a set of concerted conformational changes and the formation pores inside the membranes. Our hypothesis is that structuration can be induced by modifying the native sequence of the fusion peptides by introducing unique constrained amino acids. Following the insertion of the constrained residues, we then aim to acquire a better understanding of this family of peptides and subsequently use virus- derived molecular tools for drug vectorization purposes. The proposal will be developed in the BioCIS and ORCG laboratories (CYU (France) and VUB (Belgium)) in collaboration with partners providing molecular modelling, structural analyses. Microscopy studies will be undertaken to visualize how the modified peptide sequences behave in a cellular context. The postdoctoral position will be equally divided between each of the two laboratories (BioCIS and ORGC),.

Requirements

Research Field

Chemistry

Education Level

PhD or equivalent

Skills/Qualifications

peptides synthesis

organic chemistry

Specific Requirements

Additional skills :

peptides characterization (NMR, CD)

modeling studies

Languages

ENGLISH

Level

Good

Research Field

Chemistry » Organic chemistry

Internal Application form(s) needed

postdoc proposal 2024.pdf

English

(253.13 KB - PDF)

Download

Additional Information

Benefits

https: // box.u-cergy.fr/public/gfa-4th-call-vf

Eligibility criteria

https: // box.u-cergy.fr/public/gfa-4th-call-vf

Selection process

application with curriculum vitae, cover letter interview with the two laboratories

Website for additional job details

https: // eutopia-university.eu/english-version/opportunities/research/eutopia- si…

Work Location(s)

Number of offers available

1

Company/Institute

CY Université

Country

France

State/Province

95

City

cergy-Pontoise

Postal Code

95000

Street

5 mail gay-Lussac, Neuville sur Oise

Geofield

Number of offers available

1

Company/Institute

CY Université

Country

France

State/Province

95

City

neuville sur Oise

Postal Code

95031

Street

5 mail gay-Lussac, Neuville sur Oise

Geofield

Where to apply

E-mail

[email protected]

Contact

State/Province

Not US or Canada

City

Cergy-Pontoise

Website

https: // biocis.cyu.fr/

Street

Univ. de Cergy-Pontoise

Postal Code

95031

E-Mail

[email protected]

Phone

0648132671

STATUS: EXPIRED