Understanding The Mechanism Of Rna:Dna Hybrid Suppression By The Sfpq-Daxx Complex In Osteosarcoma

22 Aug 2023

Job Information

Organisation/Company

Università degli Studi di Trieste

Department

HR - Academic Staff

Research Field

Biological sciences » Other

Researcher Profile

Recognised Researcher (R2)

Established Researcher (R3)

Country

Italy

Application Deadline

21 Sep 2023 - 23:59 (Europe/Rome)

Type of Contract

Temporary

Job Status

Not Applicable

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Reference Number

23ar709-9/08

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

In osteosarcoma, low expression or frequent mutations of single components of the DAXX/ATRX histone H3.3 chaperon/nucleosome remodeling complex lead to increased levels of RNA:DNA hybrid related genomic stability at telomere and non-telomere sites. The project aims to understand the action of RNA:DNA hybrid binding proteins that recruit the ATRX/DAXX complex to resolve local RNA:DNA hybrids. The molecular interaction of involved players and their precise role in maintaining genome stability will be addressed. Candidates should have experience in standard methodology related cancer cell biology, immunofluorescence microscopy and cell culture techniques. Specialized experience in the analysis of genomic stability, RNA:DNA hybrids, ChIP seq, DNA replication, RNA biology and FISH technology are an additional plus during the candidate selection process.

Requirements

Research Field

Biological sciences » Other

Education Level

Master Degree or equivalent

Skills/Qualifications

Candidates should have experience in standard methodology related cancer cell biology, immunofluorescence microscopy and cell culture techniques. Specialized experience in the analysis of genomic stability, RNA:DNA hybrids, ChIP seq, DNA replication, RNA biology and FISH technology are an additional plus during the candidate selection process.

Specific Requirements

Candidates should have experience in standard methodology related cancer cell biology, immunofluorescence microscopy and cell culture techniques. Specialized experience in the analysis of genomic stability, RNA:DNA hybrids, ChIP seq, DNA replication, RNA biology and FISH technology are an additional plus during the candidate selection process.

Additional Information

Website for additional job details

https: // web.units.it/concorsi/ricerca/conc-49548

Work Location(s)

Number of offers available

1

Company/Institute

University of Trieste

Country

Italy

City

Trieste

Geofield

Where to apply

Website

https: // pica.cineca.it/units

Contact

City

Trieste

Website

https: // www. units.it/ateneo/bandi

Street

Piazzale Europa 1

Postal Code

34127

E-Mail

[email protected]

STATUS: EXPIRED