Research Group Leader: Konstantinos Tripsianes, Ph.D.
We apply structural biology methods in order to gain a mechanistic view of
CK1ε action in the Wnt signalling pathways. CK1ε represents an attractive
therapeutic target but currently two key steps in the CK1ε-mediated Wnt signal
transduction are unclear: (Project 1) how CK1ε gets activated and/or engages
target proteins in response to Wnt signal and (Project 2) how CK1ε
phosphorylates its key substrate DVL and what are the consequences of DVL
We apply methods of integrated structural biology to (i) probe the DVL
conformational landscape using in vitro and in vivo FRET sensors coupled to
SAXS and CryoEM, (ii) understand the (auto)phosphorylation regulatory
mechanisms of CK1ε, (iii) analyse by NMR the functional consequences of DVL
phosphorylation and (iv) monitor DVL phosphorylation by real-time NMR under
controlled cellular conditions.
Both positions (PhD or PostDoc level) are part of a multidisciplinary
project that combines (i) cellular and molecular biology, (ii) proteomic
analysis, (iii) biochemistry and structural biology, and received generous
funding in a very competitive grant scheme.
We are looking for highly motivated researchers with a strong background or
interest in structural biology. Hands-on experience with protein expression
and purification is prerequisite. Experience with biomolecular NMR is a plus.
Salary that will be based on the candidate's qualifications and
Background of a recognized and successful institution with supportive and
international working environment
Support with the relocation process (welcome office service)
6 weeks of paid holiday
Anticipated start date: Immediately or upon agreement.
Please send application (including CV, short statement of research
background/interests and the contact information of at least two references)
or queries by email to: firstname.lastname@example.org
Electronic application deadline is: September 30th 2021
Organisation/Company: CEITEC - Central European Institute of
The Faculty of Science, Charles University (Prague, Czechia) invites
applications for a Post-doctoral position in the Chemistry Section for the
The position is open for researchers with experience in the area of protein
The Cellular Protein Chemistry section is seeking applications.
(mutant) CFTR protein in mammalian cells and mode of action of candidate
a position for two years;
CPC is part of the Bijvoet Centre for Biomolecular Research,...
Position Number P00001 Working Title Postdoctoral Researcher - Biochemistry
and Protein Biophysics Department Chemistry Organizational Overview
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