Three-Year Postdoc Position In Pancreatic Cancer, Glycosylation And Microenvironnement

Universities and Institutes of France
February 01, 2023
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Offerd Salary:Negotiation
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Contract Type:Temporary
Working Time:Full time
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  • Organisation/Company: Aix-Marseille Université
  • Research Field: Biological sciences › Biology
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 01/02/2023 23:00 - Europe/Brussels
  • Location: France › Marseille
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/02/2023
  • The study of how cancer cells alter the glycosylation of cell surface proteins and how these modifications alter interactions between tumor cells and their environment: ECM, epithelial cells and immune system. Glycosylation is regulated by the GALA pathay. The project aims to establish whether pancreatic tumors activate GALA and whether a GALA specific treatment can improve outcomes.

    The group “ Glycosylation, Cellular INterfaces and Therapies” (GLYNTHERA) is newly formed and funded by an Excellence Chair from Amidex and the ARC grant “International Leaders in Oncology”. The position will be funded at a competitive level.

    Bibliographical references:

    Nguyen AT, Chia J, Ros M, Hui KM, Saltel F, Bard F. Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. Cancer Cell. 2017 Nov 13;32(5):639–653.e6. PMID: 29136507

    Ros M, Nguyen AT, Chia J, Le Tran S, Le Guezennec X, McDowall R, Vakhrushev S, Clausen H, Humphries MJ, Saltel F, Bard FA. ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nat Cell Biol. 2020 Nov;22(11):1371–1381. PMID: 33077910

    Benefits

    Based on experience and following INSERM guidelines.

    The Euraxess Center of Aix-Marseille Université informs foreign visiting professors, researchers, postdoc and PhD candidates about the administrative steps to be undertaken prior to arrival at AMU and the various practical formalities to be completed once in France: visas and entry requirements, insurance, help finding accommodation, support in opening a bank account, etc. More information on AMU EURAXESS Portal.

    Selection process

    CV, motivation e-mail and 2 recommendation letters

    Applications must be sent to Mr. Frédéric Bard : [email protected]

    Offer Requirements Skills/Qualifications
  • PhD in Life Sciences
  • Good mastery of biomedical lab biology techniques (Western Blot, cell culture)
  • Solid expertise in confocal microscopy and image analysis
  • Aptitude to develop protocols and perform data analysis
  • Enthusiastic about science and driven to succeed
  • Good knowledge of pancreatic cancer
  • Good knowledge of O-glycosylation regulation
  • Good English written and oral skills
  • Specific Requirements

    Analytical and critical thinking, good written and oral communication

    Contact Information
  • Organisation/Company: Aix-Marseille Université
  • Organisation Type: Higher Education Institute
  • Website: https:// www. univ-amu.fr
  • E-Mail: [email protected]
  • Country: France
  • City: Marseille
  • Postal Code: 13007
  • Street: 58 boulevard Charles-Livon (Headquaters)
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