The Molecular Machinery Of Galectin-Driven Endocytosis

28 Oct 2023

Job Information

Organisation/Company

Curie Institute - Cellular and Chemical Biology

Research Field

Biological sciences » Biology

Chemistry » Biochemistry

Researcher Profile

Recognised Researcher (R2)

Leading Researcher (R4)

First Stage Researcher (R1)

Established Researcher (R3)

Country

France

Application Deadline

26 Nov 2023 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

2 Sep 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Abstract

The internalization of extracellular and plasma membrane-localized molecules is critical for various physiological functions such as signaling, cell migration, membrane turnover, neurotransmission, metabolism, and pathogen invasion.

Several uptake mechanisms exist and act in parallel. Clathrin-mediated endocytosis is the best- characterized internalization pathway with a well- defined sequence of events and molecular machinery. Clathrin-independent endocytosis processes have also been documented, but these remain poorly explored (1,2). GlycosLipid-Lectin (GL-Lect)-driven endocytosis was pioneered in our team and belongs to the group of clathrin-independent endocytic processes.

It remains unexplored to what extent different GL-Lect driven endocytic processes share the same molecular identity (glycoproteins, glycolipids and glycans). We hypothesize the existence of a glycocode that determines the final fate of internalized cargo molecules.

With this PhD-project, we aim to test the glycocode hypothesis using our newly developed DNA-based nanotechnology for spatio-temporal multiomics.

The French or non-French PhD student will acquire and develop a broad range of expertise in molecular biology, recombinant protein purification, cell biology, analysis of omics results, lattice light-sheet microscopy and electron microscopy. The PhD student will benefit from mentoring and/or a secondment abroad through a collaborative network to gain additional training in glycobiology.

Funding category: Contrat doctoral IC-PhD - Institut Curie International PhD Program PHD title: Docteur en philosophie (Ph.D.) en Biologie PHD Country: France

Requirements

Specific Requirements

Eligibility criteria

- Master or equivalent validated by Doctoral School (to be contacted by the PIs),

- The candidate shall have completed maximum a Master I and II in France, but no Bachelor

in order to ensure an international profile of candidates.

Required documents

CV: maximum 2 pages, Master diploma or equivalent validated by Doctoral School (to be contacted by the PIs), University grades, 2 recommendation letters from teachers or researchers, 1-page motivation letter for the PhD project.

Additional Information Work Location(s)

Number of offers available

1

Company/Institute

Curie Institute - Cellular and Chemical Biology

Country

France

Where to apply

Website

https: // www. abg.asso.fr/fr/candidatOffres/show/idoffre/117513

Contact

Website

https:// institut-curie.org/team/johannes

STATUS: EXPIRED