Berkeley Lab's Environmental Genomics and Systems Biology Division (EGSB)
has an opening for a Postdoctoral Scholar to join the Center for Advanced
Bioenergy and Bioproducts Innovation (CABBI) and Biosystems Design Program,
funded by the DOE, Biological and Environmental Research (BER) Program, and
the Yoshikuni Group. These programs seek to develop non-model multi-stress
tolerant yeast strain for production of biofuels and renewable chemicals. The
successful Postdoctoral Scholar will develop a robust non-model yeast strain,
Issatchenkia orientalis, for production of organic acids and perform
subsequent integrative-omics analyses. The position will work under Staff
Scientist, Yasuo Yoshikuni.
What You Will Do:
Engineer I. orientalis strain for production of organic acid.
Identify genes involved in diversion of carbon flux from organic acid
and knock out the genes using CRISPR-Cas9.
Perform phylogenetic analyses of enzymes involved in a non-oxidative
glycolytic (NOG) pathway
Select candidate genes for synthesis and perform enzyme
Select the most active variants from the lists of above enzymes.
Build the NOG pathway to improve the yield of citramalate production.
Summarize experimental results and present them at group meetings.
Keep precise and detailed laboratory notebooks.
Manage relationships with our collaborators.
What is Required:
Ph.D. degree in Biochemistry, Microbial Metabolic Engineering, Synthetic
Biology, or a related field.
Strong motivation to contribute to develop the areas of research under
the DOE mission.
Detailed knowledge in microbial biochemistry, genetics, metabolism, and
Ability to successfully work in a dynamic team environment.
Strong written and oral communication skills.
Additional Desired Qualifications:
Experience in metabolite extraction, isolation and structure elucidation
(HPLC, LC-MS, GC, and/or GC-MS)
Experience in molecular biology techniques (molecular cloning, DNA/RNA
extraction, PCR, gel electrophoresis)
This is a full time 1-year postdoctoral appointment with the possibility
of renewal based upon satisfactory job performance, continuing
availability of funds and ongoing operational needs. You must have less
than 3 years paid postdoctoral experience. Salary for Postdoctoral
positions depends on years of experience post-degree.
M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will
be evaluated to determine if they directly relate to the responsibilities
and requirements of the position. Having a conviction history will not
automatically disqualify an applicant from being considered for
Work will be primarily performed at: Lawrence Berkeley National Lab, 1
Cyclotron Road, Berkeley, CA.
Learn about us!
Environmental Genomics and Systems Biology
Mission: Linking genome biology to ecosystem dynamics.
Vision: Sustainable solutions to energy and environmental challenges developed
through mechanistic understanding of ecosystem dynamics.
Approach: We develop systems-level models using integrated molecular
observation and controlled manipulation of model organisms and defined biomes
to design and test interventions that promote beneficial outcomes.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges
by advancing sustainable energy, protecting human health, creating new
materials, and revealing the origin and fate of the universe. Founded in 1931,
Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes.
The University of California manages Berkeley Lab for the U.S. Department of
Energy's Office of Science.
Working at Berkeley Lab has many rewards including a competitive compensation
program, excellent health and welfare programs, a retirement program that is
second to none, and outstanding development opportunities. To view information
about the many rewards that are offered at Berkeley Lab- Click Here.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative
Action Employer. All qualified applicants will receive consideration for
employment without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, age, or protected veteran
status. Berkeley Lab is in compliance with the Pay Transparency
Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster
and supplement: "Equal Employment Opportunity is the Law.
Lawrence Berkeley National Laboratory encourages applications from women,
minorities, veterans, and other underrepresented groups presently considering
scientific research careers.