#109774 Staff Associate Associate III
Filing Deadline: Wed 6/23/2021
UCSD Layoff from Career Appointment : Apply by 06/11/21 for consideration
with preference for rehire. All layoff applicants should contact their
Special Selection Applicants : Apply by 06/23/21. Eligible Special Selection
clients should contact their Disability Counselor for assistance.
The UCSD Department of Pharmacology is one of two basic science units in the
School of Medicine where world-class researchers investigate the effects of
chemical interventions on biological systems. The faculty are internationally
renowned for their strength in elucidating basic cellular and molecular
mechanisms of signal transduction that lead to innovative drug target
identification and ultimately to cutting edge drug discovery. The faculty also
plays a major role in medical and graduate student training, providing
educational and programmatic offerings that span several disciplines, and
provide diversity to meet the interests of a broad spectrum of students and
More than one hundred trainees at the graduate student and postdoctoral level,
as well as a staff of more than 50 research technicians and department
administrators interact closely with the faculty. The diverse mix of ages,
backgrounds, and talents creates a robust work environment with challenging
career opportunities and a commitment to continued growth potential. We
constantly seek to recruit highly motivated, technologically-advanced and
interested individuals to become a part of our dynamic exploratory research
and educational environment. For more information, please visit our website at
The Staff Research Associate III will contribute significant and original
ideas and methods to research projects and will independently perform a wide
variety of experimental research techniques related to cancer biology
research. Initiate, develop, implement, and ensure compliance with all
required protocols. Independently perform RNA sequencing and cell signaling
analyses, cell-sorting, immunofluorescence staining, IHC Scoring and
independently collect and analyze the resulting data. Incumbent must be
proficient working with genetically engineered mouse models of development of
nonalcoholic steatohepatitis and hepatocellular carcinoma, and human cell
lines of pancreatic cancer and hepatocellular carcinoma for investigating
novel immunotherapeutics and molecular targeted drugs.
In addition, knowledge of cell isolation from specific tissues with magnetic
beads and FACS, followed by functional analysis of these cells in the
development and progression of nonalcoholic steatohepatitis and hepatocellular
carcinoma, is of importance. Responsible for overseeing laboratory management,
mouse colony maintenance, maintaining equipment and ensuring that EH&S
regulations are met. This position is afforded significant latitude for
complex research projects, decision-making and independent judgment.
Advanced theoretical background and practical knowledge in biochemistry,
molecular biology, and pharmacology, with particular expertise in cancer
biology research as typically attained by a Bachelor's degree, or an
equivalent combination of education and experience.
Extensive experience in the generation and analysis of mouse models of
cancer, and in the generation and analysis of patient-derived xenografts
of different types of human cancer (including orthotopic transplants).
Proven ability to contribute to original project development ideas,
experimental design and strategies, as well as their implementation into a
variety of research projects.
Experience working with primary human and mouse cancer cells and mouse
models of cancer, including genetic models and human xenografts.
Advanced skill, experience, and strong knowledge in a variety of molecular
pathology and biochemical techniques including: DNA extraction, RNA
isolation, isolation of bacterial plasmids, molecular cloning, tissue
culture of human and mouse samples, histological and immunohistochemical
analyses, immunofluorescent staining and imaging, cell-sorting, SDS
Polyacrylamide and agarose gel electrophoresis, PCR and Western blots.
Proven ability and experience troubleshooting and recommending
modifications to procedures and protocols to meet the needs of research
Ability to effectively document complex research procedures, accurately
record experimental details and results, perform scientific calculations
necessary for data analysis, prepare graphs and figures to summarize
results and write reports.
Skilled in the operation, maintenance, and calibration of the laboratory
equipment including: the cryostat, the Leica SP5 confocal microscope, FACS
sorter, centrifuges, microscopes, scales, thermal cyclers, and
Ability to direct, advise, and train other lab personnel on procedures,
methods, materials, equipment, and data analysis, as well as explain
difficult concepts and safety issues involved in a wide variety of
scientific experimentation. Ability to supervise, train, provide guidance,
work direction, delegate tasks, and evaluate progress of undergraduate
students, rotation students and lab helpers.
Strong leadership and management skills sufficient to handle all aspects
of laboratory management including staff supervision, financial
accountability, safety, security, scientific project development,
inventory, organizational methods, equipment acquisition and maintenance.
Excellent interpersonal skills to communicate in person, on the phone, and
in writing to a diverse population including persons from foreign
countries, the business community, academicians, students and staff with a
high degree of diplomacy, mature judgment, tact and flexibility.
Demonstrated knowledge of NIH grant procedures and the ability to write
large NIH grants as well as the ability to assemble and coordinate large
Knowledge and experience with purchasing procedures, regulations, vendor
requirements, and maintaining budgets.
Employment is subject to a criminal background check.
Must be willing to work with hazardous materials.
Willingness to work with animals.
Ability to work evenings and weekends, if necessary.
UC San Diego Health is the only academic health system in the San Diego
region, providing leading-edge care in patient care, biomedical research,
education, and community service. Our facilities include two university
hospitals, a National Cancer Institute-designated Comprehensive Cancer Center,
Shiley Eye Institute, Sulpizio Cardiovascular Center, and several outpatient
clinics. UC San Diego Medical Center in Hillcrest is a designated Level I
Trauma Center and has the only Burn Center in the county. We invite you to
join our dynamic team!
Applications/Resumes are accepted for current job openings only. For full
consideration on any job, applications must be received prior to the initial
closing date. If a job has an extended deadline, applications/resumes will be
considered during the extension period; however, a job may be filled before
the extended date is reached.
UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All
qualified applicants will receive consideration for employment without regard
to race, color, religion, sex, national origin, disability, age, protected
veteran status, gender identity or sexual orientation. For the complete
University of California nondiscrimination and affirmative action policy see:
UC San Diego is a smoke and tobacco free environment. Please visit
smokefree.ucsd.edu for more information.
Commensurate with Experience
Days, 8 hrs/day, Monday - Friday
As a federally-funded institution, UC San Diego Health maintains a marijuana
and drug free campus. New employees are subject to drug screening.