Staff Associate Associate III

University of California, San Diego

United States

June 23, 2021

Description

#109774 Staff Associate Associate III

Filing Deadline: Wed 6/23/2021

Apply Now

UCSD Layoff from Career Appointment : Apply by 06/11/21 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants : Apply by 06/23/21. Eligible Special Selection clients should contact their Disability Counselor for assistance.

DESCRIPTION

The UCSD Department of Pharmacology is one of two basic science units in the School of Medicine where world-class researchers investigate the effects of chemical interventions on biological systems. The faculty are internationally renowned for their strength in elucidating basic cellular and molecular mechanisms of signal transduction that lead to innovative drug target identification and ultimately to cutting edge drug discovery. The faculty also plays a major role in medical and graduate student training, providing educational and programmatic offerings that span several disciplines, and provide diversity to meet the interests of a broad spectrum of students and scholars.

More than one hundred trainees at the graduate student and postdoctoral level, as well as a staff of more than 50 research technicians and department administrators interact closely with the faculty. The diverse mix of ages, backgrounds, and talents creates a robust work environment with challenging career opportunities and a commitment to continued growth potential. We constantly seek to recruit highly motivated, technologically-advanced and interested individuals to become a part of our dynamic exploratory research and educational environment. For more information, please visit our website at https:// pharmacology.ucsd.edu.

The Staff Research Associate III will contribute significant and original ideas and methods to research projects and will independently perform a wide variety of experimental research techniques related to cancer biology research. Initiate, develop, implement, and ensure compliance with all required protocols. Independently perform RNA sequencing and cell signaling analyses, cell-sorting, immunofluorescence staining, IHC Scoring and independently collect and analyze the resulting data. Incumbent must be proficient working with genetically engineered mouse models of development of nonalcoholic steatohepatitis and hepatocellular carcinoma, and human cell lines of pancreatic cancer and hepatocellular carcinoma for investigating novel immunotherapeutics and molecular targeted drugs.

In addition, knowledge of cell isolation from specific tissues with magnetic beads and FACS, followed by functional analysis of these cells in the development and progression of nonalcoholic steatohepatitis and hepatocellular carcinoma, is of importance. Responsible for overseeing laboratory management, mouse colony maintenance, maintaining equipment and ensuring that EH&S regulations are met. This position is afforded significant latitude for complex research projects, decision-making and independent judgment.

MINIMUM QUALIFICATIONS
  • Advanced theoretical background and practical knowledge in biochemistry, molecular biology, and pharmacology, with particular expertise in cancer biology research as typically attained by a Bachelor's degree, or an equivalent combination of education and experience.

  • Extensive experience in the generation and analysis of mouse models of cancer, and in the generation and analysis of patient-derived xenografts of different types of human cancer (including orthotopic transplants).

  • Proven ability to contribute to original project development ideas, experimental design and strategies, as well as their implementation into a variety of research projects.

  • Experience working with primary human and mouse cancer cells and mouse models of cancer, including genetic models and human xenografts.

  • Advanced skill, experience, and strong knowledge in a variety of molecular pathology and biochemical techniques including: DNA extraction, RNA isolation, isolation of bacterial plasmids, molecular cloning, tissue culture of human and mouse samples, histological and immunohistochemical analyses, immunofluorescent staining and imaging, cell-sorting, SDS Polyacrylamide and agarose gel electrophoresis, PCR and Western blots.

  • Proven ability and experience troubleshooting and recommending modifications to procedures and protocols to meet the needs of research projects.

  • Ability to effectively document complex research procedures, accurately record experimental details and results, perform scientific calculations necessary for data analysis, prepare graphs and figures to summarize results and write reports.

  • Skilled in the operation, maintenance, and calibration of the laboratory equipment including: the cryostat, the Leica SP5 confocal microscope, FACS sorter, centrifuges, microscopes, scales, thermal cyclers, and spectrophotometers.

  • Ability to direct, advise, and train other lab personnel on procedures, methods, materials, equipment, and data analysis, as well as explain difficult concepts and safety issues involved in a wide variety of scientific experimentation. Ability to supervise, train, provide guidance, work direction, delegate tasks, and evaluate progress of undergraduate students, rotation students and lab helpers.

  • Strong leadership and management skills sufficient to handle all aspects of laboratory management including staff supervision, financial accountability, safety, security, scientific project development, inventory, organizational methods, equipment acquisition and maintenance.

  • Excellent interpersonal skills to communicate in person, on the phone, and in writing to a diverse population including persons from foreign countries, the business community, academicians, students and staff with a high degree of diplomacy, mature judgment, tact and flexibility.

  • Demonstrated knowledge of NIH grant procedures and the ability to write large NIH grants as well as the ability to assemble and coordinate large multi-institutional grants.

  • PREFERRED QUALIFICATIONS
  • Knowledge and experience with purchasing procedures, regulations, vendor requirements, and maintaining budgets.
  • SPECIAL CONDITIONS
  • Employment is subject to a criminal background check.
  • Must be willing to work with hazardous materials.
  • Willingness to work with animals.
  • Ability to work evenings and weekends, if necessary.
  • Apply Now

    UC San Diego Health is the only academic health system in the San Diego region, providing leading-edge care in patient care, biomedical research, education, and community service. Our facilities include two university hospitals, a National Cancer Institute-designated Comprehensive Cancer Center, Shiley Eye Institute, Sulpizio Cardiovascular Center, and several outpatient clinics. UC San Diego Medical Center in Hillcrest is a designated Level I Trauma Center and has the only Burn Center in the county. We invite you to join our dynamic team!

    Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

    UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: https:// www-hr.ucsd.edu/saa/nondiscr.html

    UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

    Payroll Title:

    SRA 3

    Department:

    PHARMACOLOGY

    Salary Range

    Commensurate with Experience

    Worksite:

    La Jolla

    Appointment Type:

    Career

    Appointment Percent:

    100%

    Union:

    RX Contract

    Total Openings:

    1

    Work Schedule:

    Days, 8 hrs/day, Monday - Friday

    As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.