The Simon research group is studying regeneration processes in aquatic
salamanders. Natural examples of regeneration, such as salamanders, may
unravel novel strategies for cell replacement of damaged or lost tissues. We
study regeneration mechanisms in an aquatic salamander, the newt, which has
the widest repertoire of regenerative abilities among tetrapods. During the
past decade our laboratory has developed several methods, which has made these
outstanding questions experimentally tangible. We place our findings on newt
regeneration into an evolutionary context and test our results in a variety of
mammalian in vivo and in vitro assays. The main target tissue of our
investigations in the context of limb regeneration is skeletal muscle.
Skeletal muscle can contribute to limb regeneration in two ways, either by
activation of quiescent stem cells or by dedifferentiation of differentiated
muscle fibers. By various cell tracking strategies, we try to compare these
two processes to each other in terms of their relative contribution to the
limb. We also characterize molecular processes involved in the generation of
limb progenitors from skeletal muscle.
The successful applicant will focus on limb regeneration using state of the
art cell and molecular biological tools and will be involved in developing new
methodologies. It will be important to collaborate with other members of our
team with overlapping projects.
To qualify the person must hold a PhD degree and who is experienced in limb
regeneration studies in vertebrates. The person should have proved
skillfulness by authoring scientific papers in peer reviewed journals. Long
term experience of work with non-vertebrate and vertebrate regeneration
models, particularly Pleurodeles Waltl is an important merit.
What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote
better health for all. At Karolinska Institutet, we conduct innovative medical
research and provide the largest range of biomedical education in Sweden.
Karolinska Institutet is a state university, which entitles employees to
several benefits such as extended holiday and a generous occupational pension.
Employees also have free access to our modern gym and receive reimbursements
for medical care.
The application is to be submitted through the Varbi recruitment system. In
this recruitment, you will apply with your CV without a personal letter.
Instead, you will answer some questions about why you are applying for the job
in the application form.
Permanent position is initiated by a six months trial period.
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