Senior Biostatistician - Cancer Research UK Clinical Trials Unit - 59556 -
Grade 8 - (210001WY)
This post is open to internal applicants only
Cancer Research UK Clinical Trials Unit
Location: University of Birmingham, Edgbaston, Birmingham UK
Full time starting salary is normally in the range £42,149 to £50,296 with
potential progression once in post to £56,587 a year.
Full Time / Fixed Term Contract to 30 September 2023
Closing date 28 October 2021
As a member of the biostatistics team the post holder will play a central role
in Cancer Research UK Clinical Trials Unit's (CRCTU) research and
educational activities. They will actively liaise with clinical investigators,
contribute to the design and conduct of clinical trials, be responsible for
interim and final analysis of clinical trial data and have a key role in the
presentation and publication of results. As academic members of the
University, Biostatisticians contribute to teaching at undergraduate and
The post holder will contribute to the design and analysis of the CRCTU's
clinical trials in addition to contributing to methodological and trial-
related clinical research. The post holder will work within a large team of
biostatisticians, specialising in specific disease sites, trial phases and
methodological areas. They will have the opportunity to contribute to trial
portfolios in a variety of solid and haematological cancers and in non-cancer,
in both adult and paediatric populations. This post provides an excellent
opportunity for a bright, ambitious Biostatistician to apply their experience
and expertise within a leading academic trials unit undertaking
methodologically challenging research.
• Provide expert statistical advice for the design of clinical trials and
related studies, and develop clinical trial protocols in collaboration with
Clinical Investigators, internally and externally to the Unit.
• Take overall responsibility for the analysis of clinical trial data,
preparing and presenting reports for Data Monitoring and Steering Committees
and contributing to presentations and publications of clinical trial results.
• Collaborate with Clinical Investigators in the submission of grant
• Supervise, in collaboration with Programmers and Trial Coordinators, the
setting up of a randomisation process and development of data collections
forms and databases for trials.
• Determine appropriate statistical analysis and write statistical analysis
plans for clinical trial data, drawing upon novel methodology where
appropriate, and provide guidance to other members of the Biostatistics Team
in their analysis plans as required.
• Supervise the statistical input to assist Trial Coordinators in the running
of on-going trials and monitoring of data quality.
• Collaborate on relevant projects with researchers in other Schools within
the University of Birmingham and manage the contributions to such projects
from members of the Biostatistics Team.
• Take responsibility for statistical inputs to the Standard Operating
Procedures for the Trials Unit.
• Take the lead in statistical methodological research projects relevant to
clinical trials and associated translational research, including collaboration
with researchers at other institutions and supervision of other members of the
Biostatistics Team in methodological research
• Project-manage the statistical contributions to trials, supervising the
analysis undertaken by other members of the Biostatistics team.
• Provide supervision and mentorship for more junior staff
• Take overall responsibility for the statistical contributions to
publications of clinical papers, taking the lead when appropriate, and take
the overall lead on statistical papers.
• Present clinical trial results and methodological research at internal and
external seminars and national and international conferences.
• Provide expert statistical guidance to external bodies such as Editorial
Boards and Grant Funders.
• Represent the CRCTU at internal and external clinical and scientific
• Lecture on statistics and clinical trial methodology, marking and examining
assessments where appropriate and provide in-house staff training.
• Provide mentorship and supervision for MSc and PhD research students.
• Liaise with pharmaceutical companies in relation to trials that they
The post holder will support the delivery of clinical research in accordance
with Good Clinical Practice (GCP), the Declaration of Helsinki, applicable
legislation (including, but not limited to, the Medicines for Human Use
Clinical Trials Regulations, Data Protection Act 1998, Human Tissue Act), the
Research Governance Framework for Health and Social Care, Caldicott
principals, and applicable NHS Trust and University policies and procedures,
(including, but not limited to the University's Data Protection Policy,
Information Security Policy and Code of Practice for Research) in order to
protect the research subject and the quality of each study.
As part of their duties, the post holder will promote equality and value
diversity and inclusion through monitoring and evaluation and actively
challenging unacceptable behaviour.
Pursuit of post-graduate qualifications or personal research interests is
encouraged, providing the work is agreed in advance, is of sufficient merit
and time is available such that trial work would not suffer.
The individual suitable for this post would have experience that is relevant
to the design and analysis of clinical trials and would be capable of working
independently as a statistician on trials. They would be expected to take the
statistical lead in one or more key disease areas covered by the CRCTU within
a fairly short time of appointment.
• MSc or PhD in Statistics or relevant subject and possess substantial
previous experience of working as an applied medical statistician
Experience and knowledge
• Extensive experience in clinical trials, specifically trial design and
writing of protocols and the analysis, reporting and publication of results
• Extensive experience of applying and/or developing successful statistical
models, techniques and methods, particularly in relation to clinical trial
• Extensive experience and demonstrated success in planning, undertaking and
project managing statistical aspects of clinical trial research to deliver
high quality results
• Knowledge of statistical packages
• Experience in communicating statistical concepts to non-statisticians
• Experience in writing reports and papers for publication
• Experience of championing Equality, Diversity and Inclusion in own work area
with and ability to monitor and evaluate the extent to which equality and
diversity legislation, policies, procedures are applied as well as the ability
to identify issues with the potential to impact on protected groups and take
Abilities and skills
• Ability to lecture and present
• Ability to work well both on own initiative and within a team
• Evidence of good inter-personal, verbal and written communication skills
• Aptitude to manage and mentor staff
• Ability to contribute to the operational management of the biostatistics
• Ability to apply novel trial methodology in real-world settings
Further particulars can be found here:
https:// www. download.bham.ac.uk/vacancies/jd/MDSFPs.pdf
Informal enquires can be made to Professor Lucinda Billingham at
L.J.Billingham@bham.ac.uk or Aimee Jackson at A.E.Jackson@bham.ac.uk
Valuing excellence, sustaining investment
We value diversity and inclusion at the University of Birmingham and
welcome applications from all sections of the community and are open to
discussions around all forms of flexible working
Cancer Research Clinical Trials Unit, 1st Floor
Robert Aitken Building, Vincent Drve The University of BirminghamEdgbaston
Birmingham B15 2TT
: Academic Non-clinical
: Cancer and Genomic Sciences
: 07.10.2021, 8:06:31 PM
Grade (for job description): Grade 8
Salary (Pay Basis)
Advert Close Date
: 29.10.2021, 5:59:00 AM