Senior Biostatistician - Cancer Research UK Clinical Trials Unit - 59556 - Grade 8

University of Birmingham

United Kingdom

October 28, 2021


Senior Biostatistician - Cancer Research UK Clinical Trials Unit - 59556 - Grade 8 - (210001WY)


Position Details

This post is open to internal applicants only

Cancer Research UK Clinical Trials Unit

Location: University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £42,149 to £50,296 with potential progression once in post to £56,587 a year.

Grade 8

Full Time / Fixed Term Contract to 30 September 2023

Closing date 28 October 2021

Job Summary

As a member of the biostatistics team the post holder will play a central role in Cancer Research UK Clinical Trials Unit's (CRCTU) research and educational activities. They will actively liaise with clinical investigators, contribute to the design and conduct of clinical trials, be responsible for interim and final analysis of clinical trial data and have a key role in the presentation and publication of results. As academic members of the University, Biostatisticians contribute to teaching at undergraduate and postgraduate level.

The post holder will contribute to the design and analysis of the CRCTU's clinical trials in addition to contributing to methodological and trial- related clinical research. The post holder will work within a large team of biostatisticians, specialising in specific disease sites, trial phases and methodological areas. They will have the opportunity to contribute to trial portfolios in a variety of solid and haematological cancers and in non-cancer, in both adult and paediatric populations. This post provides an excellent opportunity for a bright, ambitious Biostatistician to apply their experience and expertise within a leading academic trials unit undertaking methodologically challenging research.

Main Duties/Responsibilities

• Provide expert statistical advice for the design of clinical trials and related studies, and develop clinical trial protocols in collaboration with Clinical Investigators, internally and externally to the Unit.

• Take overall responsibility for the analysis of clinical trial data, preparing and presenting reports for Data Monitoring and Steering Committees and contributing to presentations and publications of clinical trial results.

• Collaborate with Clinical Investigators in the submission of grant applications.

• Supervise, in collaboration with Programmers and Trial Coordinators, the setting up of a randomisation process and development of data collections forms and databases for trials.

• Determine appropriate statistical analysis and write statistical analysis plans for clinical trial data, drawing upon novel methodology where appropriate, and provide guidance to other members of the Biostatistics Team in their analysis plans as required.

• Supervise the statistical input to assist Trial Coordinators in the running of on-going trials and monitoring of data quality.

• Collaborate on relevant projects with researchers in other Schools within the University of Birmingham and manage the contributions to such projects from members of the Biostatistics Team.

• Take responsibility for statistical inputs to the Standard Operating Procedures for the Trials Unit.

• Take the lead in statistical methodological research projects relevant to clinical trials and associated translational research, including collaboration with researchers at other institutions and supervision of other members of the Biostatistics Team in methodological research

• Project-manage the statistical contributions to trials, supervising the analysis undertaken by other members of the Biostatistics team.

• Provide supervision and mentorship for more junior staff

• Take overall responsibility for the statistical contributions to publications of clinical papers, taking the lead when appropriate, and take the overall lead on statistical papers.

• Present clinical trial results and methodological research at internal and external seminars and national and international conferences.

• Provide expert statistical guidance to external bodies such as Editorial Boards and Grant Funders.

• Represent the CRCTU at internal and external clinical and scientific meetings.

• Lecture on statistics and clinical trial methodology, marking and examining assessments where appropriate and provide in-house staff training.

• Provide mentorship and supervision for MSc and PhD research students.

• Liaise with pharmaceutical companies in relation to trials that they support.

The post holder will support the delivery of clinical research in accordance with Good Clinical Practice (GCP), the Declaration of Helsinki, applicable legislation (including, but not limited to, the Medicines for Human Use Clinical Trials Regulations, Data Protection Act 1998, Human Tissue Act), the Research Governance Framework for Health and Social Care, Caldicott principals, and applicable NHS Trust and University policies and procedures, (including, but not limited to the University's Data Protection Policy, Information Security Policy and Code of Practice for Research) in order to protect the research subject and the quality of each study.

As part of their duties, the post holder will promote equality and value diversity and inclusion through monitoring and evaluation and actively challenging unacceptable behaviour.

Pursuit of post-graduate qualifications or personal research interests is encouraged, providing the work is agreed in advance, is of sufficient merit and time is available such that trial work would not suffer.

Person Specification

The individual suitable for this post would have experience that is relevant to the design and analysis of clinical trials and would be capable of working independently as a statistician on trials. They would be expected to take the statistical lead in one or more key disease areas covered by the CRCTU within a fairly short time of appointment.


• MSc or PhD in Statistics or relevant subject and possess substantial previous experience of working as an applied medical statistician

Experience and knowledge

• Extensive experience in clinical trials, specifically trial design and writing of protocols and the analysis, reporting and publication of results

• Extensive experience of applying and/or developing successful statistical models, techniques and methods, particularly in relation to clinical trial data

• Extensive experience and demonstrated success in planning, undertaking and project managing statistical aspects of clinical trial research to deliver high quality results

• Knowledge of statistical packages

• Experience in communicating statistical concepts to non-statisticians

• Experience in writing reports and papers for publication

• Experience of championing Equality, Diversity and Inclusion in own work area with and ability to monitor and evaluate the extent to which equality and diversity legislation, policies, procedures are applied as well as the ability to identify issues with the potential to impact on protected groups and take appropriate action.

Abilities and skills

• Ability to lecture and present

• Ability to work well both on own initiative and within a team

• Evidence of good inter-personal, verbal and written communication skills

• Aptitude to manage and mentor staff

• Ability to contribute to the operational management of the biostatistics team

• Ability to apply novel trial methodology in real-world settings

Further particulars can be found here: https:// www.

Informal enquires can be made to Professor Lucinda Billingham at or Aimee Jackson at

Valuing excellence, sustaining investment

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working


Primary Location

: GB-GB-Birmingham

Work Locations


Cancer Research Clinical Trials Unit, 1st Floor

Robert Aitken Building, Vincent Drve The University of BirminghamEdgbaston

Birmingham B15 2TT


: Academic Non-clinical


: Cancer and Genomic Sciences


: Temporary


Job Posting

: 07.10.2021, 8:06:31 PM

Grade (for job description): Grade 8

Salary (Pay Basis)

: 42,149.00

Maximum Salary

: 56,587.00

Advert Close Date

: 29.10.2021, 5:59:00 AM