Scholarship in Biology: evolution and genetic drivers of sex chromosome dynamics

Vrije Universiteit Brussel
October 01, 2023
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Scholarship in Biology: evolution and genetic drivers of sex chromosome

dynamics

Category: PhD

1 - Working at the VUB

For more than 50 years, the Vrije Universiteit Brussel has stood for f reedom, equality and solidarity , and this is very much alive on our campuses among students and staff alike.

At the VUB, you will find a diverse collection of personalities: innovators pur sang, but above all people who are 100% their authentic selves. With some 4,000 employees , we are the largest Dutch-speaking employer, in the private sector, in Brussels ; an international city with which we are only too happy to connect and where (around) our 4 campuses are located.

Add to this our principle of free research - in which self-reflection, a critical attitude and an open, creative mind around scientific and social issues are central - and you have a university that is fundamentally groundbreaking and pioneering in education and research. In short: the VUB all over again.

Moreover, the VUB is a member of EUTOPIA , an alliance of like-minded European universities, all ready to reinvent themselves.

2 - Position description

The Faculty of Sciences and Bioengineering Sciences , Department Department of Biology , is looking for a PhD-student with a doctoral grant.

More concretely your work package, for the preparation of a doctorate , contains:

4-year ERC-grant funded PhD scholarship on evolution and genetic drivers of sex chromosome dynamics in frogs is available in the Ma lab (https: // www. wmalab.com) at Vrije Universiteit Brussel (VUB), situated in the heart of Brussels, Belgium.

The Ma lab is interested in how sex chromosomes evolve, and why the evolutionary trajectories of sex chromosomes differ dramatically across eukaryotes. For example, sex determination is very labile in reptiles, amphibians and fishes but highly stable in mammals and most birds. We study the drivers of sex chromosome recombination suppression, the genomic signature, and the evolution and genomic basis of sex determination as well as endosymbiont manipulation of host reproduction. We integrate comparative and functional genomics, transcriptomics, molecular genetics, artificial selection, and fieldwork sampling to reveal the genomic signature and genetic architecture of sex.

Topic: Evolution and genetic drivers of sex chromosome dynamics

Unlike highly degenerated Y and W chromosomes in mammals and birds, many non- model organisms have shown a huge diversity in sex chromosome differentiation rate and genetic mechanism. Specifically, in amphibians, fishes, many reptiles and angiosperm plants, sex chromosomes are little degenerated and remain largely identical in size. Fascinatingly, many of these lineages show a frequent birth and death of sex chromosomes (turnover). The reason why sex chromosome evolutionary trajectories differ so dramatically across eukaryotes is an unresolved and fundamental question in evolutionary biology.

Frogs are excellent systems for advancing our understanding of sex chromosome diversity and evolution. This project will be focusing on identifying sex chromosome systems in various frog lineages in a phylogenetic framework and investigate the underlying evolutionary forces and genetic drivers for the frequent birth and death of sex chromosomes, involving functional molecular work on key candidate genes.

For this function, our Brussels Humanities, Sciences & Engineering Campus (Elsene) will serve as your home base.

3 - Profile

What do we expect from you?

Master degree

  • Applicants from a variety of backgrounds are welcome, but we are particularly interested in those with a strong interest in field sampling, evolution, genetics & genomics, and molecular biology.

  • You have not performed any works in the execution of a mandate as an assistant, paid from operating resources, over a total (cumulated) period of more than 12 months.

  • The VUB wants to be a reflection of the society where everyone's talent is valued, regardless of gender, age, religion, skin color, migration background, disability and neurodiversity.

    4 - Offer

    Are you going to be our new colleague?

    You'll be offered a full-time PhD-scholarship , for 12 months (extendable up to max. 48 months, on condition of the positive evaluation of the PhD activities), with planned starting date 15/11/2023.

    You'll receive a grant linked to one of the scales set by the government.

    IMPORTANT: The effective result of the doctorate scholarship is subject to the condition precedent of your enrolment as a doctorate student at the university.

    At the VUB, you're guaranteed an open, involved and diverse workplace where you are offered opportunities to (further) build on your career.

    As well as this, you will also enjoy various other benefits :

  • Extensive homeworking options , a telework allowance of 50 euros per month OR an internet fee of 20 euros per month;
  • An open and informal working environment where attention is paid to work-life balance , and exceptional holiday arrangements with 35 days of leave (based on a fulltime contract), closure between Christmas and New Year and 3 extra leave days;
  • Cost-free hospitalisation insurance ;
  • Full reimbursement of your home-to-work commute with public transport according to VUB-policy, and/or compensation if you come by bike;
  • A wide selection of meals in our campus restaurants at attractive prices;
  • Excellent and affordable facilities for sport and exercise , a range of discounts via Benefits@Work (in all kinds of shops, on flights, in petrol stations, amusement parks...) and Ecocheques ;
  • Nursery near campus, discount on holiday camps ;
  • The space to form your job content and to continuously learn through our VUB learning platforms and training courses;
  • And finally: great colleagues with a healthy drive.
  • 5 - Interested?

    Is this the job you've been dreaming of?

    Then apply, at the latest on 10/10/2023 , via jobs.vub.be, and upload the following documents:

  • your CV;
  • your motivation letter;
  • your diploma (not applicable for VUB alumni).
  • Do you have questions about the job content? Contact Prof. W.-J. Ma at wen- [email protected] or on 02/629.34.16.

    Would you like to know what it's like to work at the VUB? Go to jobs.vub.be, and find all there is to know about our campuses, benefits, strategic goals and your future colleagues.

    Would you like more information about EUTOPIA? Go to eutopia-university.eu, and read more about the role of the VUB in the development of the EUTOPIA alliance.

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