Researcher Position – Duralayer Project

Universities and Institutes of France

France

October 17, 2022

Description

  • Organisation/Company: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
  • Research Field: Biological sciences › Biological engineering Engineering › Biomaterial engineering
  • Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2)
  • Application Deadline: 17/10/2022 17:00 - Europe/Brussels
  • Location: France › COMPIEGNE
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 02/11/2022
  • Université de technologie de Compiègne is seeking to fill a researcher position for the DuraLayer project, at its Department of Bioengineering - Biomechanics and Bioengineering (BMBI) Laboratory.

    Place of work

    Compiègne

    Type of contract and anticipated starting date

    24-month fixed-term contract, as soon as possible and before January 14th, 2023.

    Experience

    This position would represent an initial professional experience for someone who has recently (< 4 years) obtained their PhD in a field relevant to the project.

    Gross monthly salary

    € 2 800 € based on experience and funding

    Workload

    1 607 hours per annum

    Context

    Substitutes of dura mater (half-rigid membrane located between bone and nervous system) used in case of substance loss or for post-op wound healing can still lead to complications. Our team aims at developing new biomaterials mimicking the multiphasic structure of native dura mater to face this challenge, thanks to phases and interphases with refined, specific biomechanical properties. Electrospinning of natural and synthetic polymer solutions will enable the development of fibre networks with properties similar to the dural extracellular matrix. Phases with relevant biomechanical properties promoting respectively osteointegration, watertightness or wound healing will be developed then combined to be used as implantable materials or coating on medical devices.

    Mission

    The post-doctoral research assistant will therefore work on the development and characterization of multiphasic materials produced by electrospinning for healthcare applications. The project will involve the use of both commercial and homemade electrospinning devices, the development of new composite biomaterials and their physico-chemical characterization, and the combinations of the different phases. The project will then rapidly focus on the culture of human stem cells and dural cells on these scaffolds, and the characterization of their biological properties (proliferation, viability, differentiation). In vivo testing is considered in case of significant progresses.

    Principal activities

  • Set-up of electrospinning devices for the fabrication of multiphasic structures.
  • Characterization (viscosity, elasticity, wettability, watertightness, alignment, degradability, rugosity…) and optimisation of polymer solutions and fibre networks.
  • Use of the biomaterials as scaffolds for human cell culture (stem cells, dural fibroblasts and their co-culture) and study of biocompatibility and cell functionality.
  • Design and possibly achievement of in vivo proof-of-concept in a rodent model.
  • Set-up and writing of experimental protocols.
  • Supervision of interns and PhD students.
  • Writing of scientific publications, oral presentation in congresses.
  • Benefits

    Gross monthly salary

    € 2 800 € based on experience and funding

    Selection process

    Academic contact

    Timothée BAUDEQUIN, UTC BMBI Laboratory.

    timothee.baudequin@utc.fr

    Application

    CV and covering letter to be uploaded to:

    https: // candidature.utc.fr/chercheur

    Following an initial screening of applications, the final decision will be based on a interview.

    Web site for additional job details

    https: // www. utc.fr/recherche/

    https: // bmbi.utc.fr/

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Engineering: PhD or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Good

    ENGLISH: Good

    Skills/Qualifications

    Skills

  • Set-up and use of electrospinning devices.
  • Development and characterization of polymeric (bio)materials, in particular local and global mechanical properties.
  • Cell culture and co-culture in sterile conditions (BSL 2).
  • A first experience with adipose-derived stem cells, dural cells and/or with silk fibroin-based materials (including fibroin extraction) would be an important asset.
  • A first experience in animal testing (rodent model) would be an interesting asset.
  • Interest for research projects at the interface between different fields.
  • Other skills: project management, rigorous experimental design, fluent in French and/or English, good writing skills in particular for experimental reports and publications, anticipation and adaptation skills, team spirit.
  • Qualification

    PhD focusing on cell biology, biomaterials, biomechanics, tissue engineering…

    Contact Information
  • Organisation/Company: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
  • Department: Department of Bioengineering - Biomechanics and Bioengineering (BMBI) Laboratory
  • Organisation Type: Higher Education Institute
  • Website: https: // bmbi.utc.fr/
  • E-Mail: timothee.baudequin@utc.fr
  • Country: France
  • City: COMPIEGNE
  • State/Province: Hauts de France
  • Postal Code: 60200
  • Street: Centre de recherche rue personne de Roberval
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