Researcher in Signal Transduction

Karolinska Institute Stockholm

Sweden

June 13, 2021

Description

Do you want to contribute to top quality medical research?

The overall research interest is to understand signal-transduction in the pancreatic beta cell, with the aim to understand the many molecular interactions generated by glucose metabolism and leading to insulin secretion.

Your mission

The successful applicant is expected to work on a collaborative project aiming at generating synthetic islet organoids modified to optimize beta cell function and survival or, alternatively, engineered to continuously produce and secrete active peptides and hormones of choice; for example, compounds regulating insulin secretion, calcium signaling, appetite or calcium metabolism. Synthetic modifications can include genetic engineering as well as manipulation of the endocrine cell composition and cytoarchitecture within pseudoislet. The applicant will be responsible for generating pseudoislets as well as assessing their functional properties both in vitro and in vivo.

Your profile

We are looking for a highly motivated candidate who would have combined expertise in the fields of islet biology, chemosensory sciences, nutritional physiology and feeding behavior. An ideal candidate should hold a PhD in Physiology and have minimum of 5 years of postdoctoral research experience in the field of islet biology. This is a demanding position that would require solid background in laboratory animal research as well as knowledge of a number of in vitro and in vivo techniques. The work on the specified project requires prior documented experience with methods of assessment of islet function including but not limited to glucose- stimulated insulin secretion and calcium imaging, and generation of islet-like organoids from islet cells (pseudoislets). Familiarity with in vitro and in vivo islet imaging by laser scanning confocal microscopy, immunohistochemistry, flow cytometry and in situ hybridisation techniques will be required for the evaluation of the success of genetic modifications of organoids. The candidate must be experienced with carrying out intraperitoneal and oral glucose tolerance tests as well as insulin tolerance tests in small rodents. Solid background in calcium metabolism and extensive documented experience with techniques to evaluate taste function, feeding and drinking behavior in rodents are required.

A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after the defense of his or her doctoral thesis.

Bases os assessment

We stress research expertise when assessing applicants.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care. The applicant should have excellent presentation and communication skills in both written and spoken English, Swedish is a plus.

Location: Solna

Read more: https:// ki.se/en/mmk/signal-transduction

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 13 June 2021

The application is to be submitted through the Varbi recruitment system.

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

Type of employment Permanent position
Contract type Full time
Salary Månadslön
Number of positions 1
Working hours 100 %
City Stockholm
County Stockholms län
Country Sweden
Reference number STÖD 2-2672/2021
Contact
  • Per-Olof Berggren, Professor, per-olof.berggren@ki.se
Union representative
  • Virpi Töhönen, SACO, virpi.tohonen@ki.se
  • Taher Darreh-Shori, SACO, 08-524 835 29
  • Elisabeth Noren-Krog, OFR, elisabeth.noren-krog@ki.se
Published 01.Jun.2021
Last application date 13.Jun.2021 11:59 PM CET