Do you want to contribute to top quality medical research?
The overall research interest is to understand signal-transduction in the
pancreatic beta cell, with the aim to understand the many molecular
interactions generated by glucose metabolism and leading to insulin secretion.
The successful applicant is expected to work on a collaborative project aiming
at generating synthetic islet organoids modified to optimize beta cell
function and survival or, alternatively, engineered to continuously produce
and secrete active peptides and hormones of choice; for example, compounds
regulating insulin secretion, calcium signaling, appetite or calcium
metabolism. Synthetic modifications can include genetic engineering as well as
manipulation of the endocrine cell composition and cytoarchitecture within
pseudoislet. The applicant will be responsible for generating pseudoislets as
well as assessing their functional properties both in vitro and in vivo.
We are looking for a highly motivated candidate who would have combined
expertise in the fields of islet biology, chemosensory sciences, nutritional
physiology and feeding behavior. An ideal candidate should hold a PhD in
Physiology and have minimum of 5 years of postdoctoral research experience in
the field of islet biology.
This is a demanding position that would require solid background in laboratory
animal research as well as knowledge of a number of in vitro and in vivo
The work on the specified project requires prior documented experience with
methods of assessment of islet function including but not limited to glucose-
stimulated insulin secretion and calcium imaging, and generation of islet-like
organoids from islet cells (pseudoislets). Familiarity with in vitro and in
vivo islet imaging by laser scanning confocal microscopy,
immunohistochemistry, flow cytometry and in situ hybridisation techniques will
be required for the evaluation of the success of genetic modifications of
The candidate must be experienced with carrying out intraperitoneal and oral
glucose tolerance tests as well as insulin tolerance tests in small rodents.
Solid background in calcium metabolism and extensive documented experience
with techniques to evaluate taste function, feeding and drinking behavior in
rodents are required.
A person is eligible to be appointed Researcher if he or she has been awarded
a Degree of Doctor or has achieved the corresponding scientific competence, as
well as documented research after the defense of his or her doctoral thesis.
Bases os assessment
We stress research expertise when assessing applicants.
What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote
better health for all. At Karolinska Institutet, we conduct innovative medical
research and provide the largest range of biomedical education in Sweden.
Karolinska Institutet is a state university, which entitles employees to
several benefits such as extended holiday and a generous occupational pension.
Employees also have free access to our modern gym and receive reimbursements
for medical care.
The applicant should have excellent presentation and communication skills in
both written and spoken English, Swedish is a plus.
Read more: https:// ki.se/en/mmk/signal-transduction
We prefer that Your application is written in English, but You can also apply
in Swedish. An application must contain the following documents: Resumé,
qualifications and description of planned research, presented in accordance
with Karolinska Institutet's qualifications portfolio.
Welcome to apply at the latest 13 June 2021
The application is to be submitted through the Varbi recruitment system.
Permanent position are initiated by a six months trial period.
Want to make a difference? Join us and contribute to better health for all
|Type of employment
|Number of positions
|Last application date
||13.Jun.2021 11:59 PM CET