Researcher in physical chemistry

Lund University

Sweden

August 16, 2022

Description

Lunds universitet, Naturvetenskapliga fakulteten, kemiska institutionen

Lund University was founded in 1666 and is repeatedly ranked among the world's top 100 universities. The University has around 44 000 students and more than 8 000 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset.

Subject description The present project area lies within colloid and interface science, a sub- discipline of physical chemistry. Focusing on the interaction of nanomaterials with lipid membranes, the project also includes aspects of biology and biophysics.

Work duties The purpose of the project is to elucidate mechanisms underlying oxidative degradation of key components in bacterial cell walls, notably phospholipids and lipopolysaccharides, as well as how this translates into antimicrobial and anti-inflammatory effects of photocatalytic nanomaterials. Addressing this, photocatalytic nanoparticles will be investigated regarding their effects on bacteria-mimicking phospholipid membranes and bacterial lipopolysaccharides. Scattering and surface chemistry techniques will be employed to investigate structural and compositional effects on exposure to photocatalytic nanoparticles in the absence and presence of illumination. The physicochemical results will be correlated to antimicrobial, anti-inflammatory, and cell toxicity effects of the photocatalytic nanoparticles. In addition, loading the particles with antimicrobial peptides will be used to boost selectivity for bacterial cell walls. Through this, we aim to contribute to a mechanistic understanding of how photocatalytic nanoparticles can be designed to potently destabilize bacterial membranes without causing adverse effects, e.g., related to oxidative destabilization of human cell membranes or release of inflammatory lipopolysaccharide fragments.

The main duty of the successful candidate will be to execute research in the subject area outline above. Additional tasks include:

  • Coordination of collaborations within the subject area with international partners
  • Co-supervision of degree projects and doctoral students
  • Responsibility for managing selected laboratory instrumentation
  • Administration related to the work duties listed above
  • Qualification requirements Applicants must have:

  • A PhD or equivalent research qualification within the subject of the position.
  • Very good oral and written proficiency in English.
  • Strong documented research experience within the area of lipid membrane interactions of nanoparticles, as well as broad experience of surface chemistry techniques (e.g., QCM-d, SAXS, neutron reflectometry, and neutron scattering) for investigating such systems.
  • Assessment criteria and other qualifications

  • Hands-on experience with research within colloid and interface science, and a background in surface chemistry, physical chemistry, or biophysics, is an advantage.
  • Experience with surface chemistry methodologies for investigating self- assembly systems (SAXS) and biological (model) systems at interfaces (QCM-d, neutron reflectometry, neutron scattering) is an advantage.
  • Experience of surface chemical studies of lipid membrane interactions with nanoparticles, and particularly so for inorganic and photocatalytic nanoparticles, is an advantage.
  • Experience of studies of lipopolysaccharide-nanoparticle interactions is an advantage.
  • Consideration will also be given to good collaborative skills, drive and independence, how the applicant's experience and skills complement and strengthen ongoing research within the department, and how they stand to contribute to its future development.

    Terms of employment The position is a fixed term employment (Särskild visstidsanställning) for 12 months, at 100 per cent of full time with preferred starting date 2022-11-01, or by agreement.

    Contact person: Professor Martin Malmsten, martin.malmsten@fkem1.lu.se, phone number +45 31 49 92 03.

    Instructions on how to apply Applications shall be written in English and be compiled into a PDF-file containing:

  • résumé/CV, including a list of publications,
  • a general description of past research and future research interests (no more than three pages),
  • contact information of at least two references,
  • copy of the doctoral degree certificate, and other certificates/grades that you wish to be considered.
  • The Faculty of Science conducts research and education within Biology, Astronomy, Physics, Geosciences, Chemistry, Mathematics and Environmental Science. The Faculty is organized into nine departments, gathered in the northern campus area. The Faculty has approximately 1500 students, 330 PhD students and 700 employees.

    We kindly decline all sales and marketing contacts.

    Type of employment Temporary position longer than 6 months

    Contract type Full time First day of employment 2022-11-01, or by agreement Salary Monthly salary Number of positions 1 Working hours 100 City Lund County Skåne län Country Sweden Reference number PA2022/2590 Contact

  • Martin Malmsten, +4531499203
  • Union representative

  • OFR/ST:Fackförbundet ST:s kansli, 046-2229362
  • SACO:Saco-s-rådet vid Lunds universitet, 046-2229364
  • SEKO: Seko Civil, 046-2229366
  • Published 03.Aug.2022 Last application date 16.Aug.2022 11:59 PM CEST

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