Researcher in Cancer Immunotherapy

Uppsala University

Sweden

October 25, 2021

Description

Researcher in Cancer Immunotherapy

Published: 2021-10-07

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden's most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.

The Department of Immunology, Genetics and Pathology at Uppsala University (www. igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 400 million, out of which more than half is made up of external funding. The staff amounts to approximately 340 employees, out of which 100 are PhD-students, and there are in total more than 600 affiliated people.

Read more about our benefits and what it is like to work at Uppsala University

Project information

Cancer immunotherapy against the PD1/L1 axis has achieved remarkable benefits in patients. However, challenges remain as >80% of patients fail to respond to the treatment. Our research group aims to dissect the resistance mechanisms by elucidating interactions between the human immune system and cancer cells. We focus on studying the negative regulatory mechanisms which cancer cells employ to hamper efficient anti-tumor immunity. In this project, we will develop CRISPR/Cas9-based precise genome editing capabilities to investigate the immune evasion mechanisms in human myeloid cells. The project will identify and investigate novel pathways or drug targets that could enable immune cell- mediated elimination of cancer cells. We believe that this project will provide significant knowledge to advance our understanding and bring benefits to patients who are currently less likely to benefit from immunotherapy. We offer significant training opportunities in translational cancer immunology research through our scientific network in academia and pharmaceutical industry and prioritize individual development of the group members. For more information, please read at https: // www. scilifelab.se/ researchers/yumeng- mao/.

Requirements

We are looking for a motivated researcher with a strong expertise and documented experience in translational cancer immunology and immunotherapy. The candidate should have completed her/his Swedish doctoral (or foreign equivalent) training in cancer immunology, immunology, cancer biology or other relevant areas within four (4) years at the application deadline. The candidate is required to have experiences in handling and isolating primary human immune cells and analyzing immune cell phenotype and functions using advanced flow cytometry. In addition, the applicant must have proven experience in using CRISPR/Cas9 system to modify functions in human cancer and primary immune cells as well as using in vivo mouse models to study the efficacy and functions of cancer immunotherapeutics. It is essential for the candidate to demonstrate solid experience in cell and molecular biology techniques, western blotting, ELISA, PCR, handling of blood products. Experiences with scientific software such as Graphpad, Flowjo, EndNote are also required. It is also expected that the candidate should be confident in conducting scientific discussions and is willing to collaborate with others as well as working independently.

Additional qualifications

It is considered a merit if the candidate has experiences in co-culture models using human cancer cells and primary immune cells. Previous publications in peer-reviewed scientific journals as a lead author or oral presentations at international conferences are considered advantageous. Interest or knowledge on myeloid cell biology is viewed positively too.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University's excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

About the employment The employment is a temporary position, 12 months. Scope of employment 100 %. Starting date 2022-02-19 or as agreed. Placement: Uppsala.

For further information about the position, please contact: Yumeng Mao, 0732676821, yumeng.mao@igp.uu.se .

Please submit your application by 25 October 2021, UFV-PA 2021/3742.

Are you considering moving to Sweden to work at Uppsala University? Find out more about what it´s like to work and live in Sweden.

Please do not send offers of recruitment or advertising services.

Submit your application through Uppsala University's recruitment system.

Placement: Department of Immunology, Genetics and Pathology

Type of employment: Full time , Temporary position longer than 6 months

Pay: Individual salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben seko@uadm.uu.se ST/TCO tco@fackorg.uu.se Saco-rådet saco@uadm.uu.se

Number of reference: UFV-PA 2021/3742

Last application date: 2021-10-25

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