The position is in the Roussarie lab, in the Department of Anatomy &
Neurobiology, which investigates the molecular basis of neurodegeneration in
Alzheimer's disease. The lab studies the selective vulnerability of a
particular set of neurons as a way to identify genes involved in
neurodegeneration. The position will facilitate research on selective neuronal
vulnerability by using an array of different techniques and working closely
with the PI and future lab members. More generally, the position will be
responsible for ensuring continuity and consistency in the lab protocols,
reagents and biological materials used by lab students and postdocs.
More specifically, the position will manage day-to-day activities in the lab
including keeping track of routine reagent stocks, placing orders, maintaining
inventories of lab biological samples and lab protocols, training novel lab
members on equipment and procedures. The position will also maintain the mouse
colony. By setting up mouse breeding pairs, weaning and genotyping mice, and
timing mouse pregnancies, the position will generate mouse cohorts that will
be used for stereotaxic injections, for cell-type specific profiling, for the
quantification of Alzheimer's disease related pathology, and for mouse neuron
primary cultures. The position will routinely produce cells for lab
experiments, both mouse primary neurons grown from mouse embryos and human
neurons differentiated from induced pluripotent stem cells. The position will
perform stereotactic injections of viruses in the mouse brain for modulating
gene expression in a cell-type specific way. Lastly, in these different study
systems as well as in human postmortem tissue, the position will use
histological and biochemical assay to evaluate Alzheimer's related pathology.
This is an exciting opportunity to be part of new BU team, and to gain solid
knowledge on molecular neuroscience and Alzheimer's disease.
Bachelor's degree and 1-3 years of experience required.
We are an equal opportunity employer and all qualified applicants will receive
consideration for employment without regard to race, color, religion, sex,
sexual orientation, gender identity, national origin, disability status,
protected veteran status, or any other characteristic protected by law. We are
a VEVRAA Federal Contractor.
BOSTON, Massachusetts, United States