Research Laboratory Tech Senior / Intermediate

University of Michigan

United States

October 14, 2021


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Job Summary

We are seeking a dedicated individual to join our laboratory team which is focused on organogenesis of the intestine. The applicant must have a Bachelor's degree (Master's degree desired) and a minimum of 2 years of relevant post-baccalaureate experience. Daily duties would include participating in all aspects of bench-side research (including but not limited to: human intestinal organoid culture, rodent recovery surgery including kidney capsule transplantation and osmotic pump placement, mouse breeding, genotyping, dissections, tissue fixation and processing, confocal and light microscopy, data recording, image processing, cell culture, tissue explant culture). Additionally, the individual would take a primary role in overseeing the management of the mouse colony for the laboratory. This position may also include mentoring of undergraduate students and oversight of other lab personnel. The ideal applicant will actively read relevant literature and participate intellectually as well as technically; co- authorship on manuscripts is expected where contributions warrant.

The successful candidate should have: outstanding interpersonal skills, experience working with advanced molecular biology tools and tissue culture methods, an understanding of human and mouse genetics and use of transgenic and knock-out mouse lines and experience in mouse breeding and colony maintenance.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

  • Excellent medical, dental and vision coverage effective on your very first day
  • 2:1 Match on retirement savings
  • Responsibilities
  • Laboratory management will include but not be limited to: oversee day-to-day operations of the laboratory, lab supply ordering, personnel scheduling, maintenance of detailed records/procedures, and maintenance of regulatory compliance documentation (5%).
  • The candidate will actively participate in project planning and coordination of projects with other laboratories (10%).
  • Oversight of mouse colony maintenance and preparation for experiments including, but not limited to: weaning, placing ear tags, collecting ear punches, genotyping, checking copulatory plugs, oral gavage feeding of tamoxifen, feeding of doxycycline chow and doxycycline water (10%).
  • DNA/RNA isolation & purification methods, PCR, tissue embedding, vibratome sectioning, paraffin sectioning, frozen sectioning, immunostaining, H&E staining, fluorescent RNA in situ hybridization, brightfield imaging, widefield fluorescence imaging, confocal imaging (35%).
  • Advanced 3D cell culture of human intestinal organoids including media preparation, changing media, and organoid culture (30%).
  • Assist in surgical procedures on mice including transplantation of human intestinal organoids under the host kidney capsule and placement of osmotic pumps (5%).
  • The candidate will assist (co-author) in the preparation of research papers, meeting presentations, and grant proposals (5%).
  • Required Qualifications
  • Bachelor's degree in a relevant field with at least 2 years' experience in a cellular and molecular biology research lab.
  • Experience in advanced tissue culture.
  • Experience in molecular biology tools (DNA/RNA purification, DNA transfection, qRT-PCR, Western Blot).
  • Experience in mouse handling and care.
  • Outstanding interpersonal skills - the applicant must have the ability to work independently, and in a diverse team environment.
  • Ability to multi-task, prioritize efforts, and execute independently and collaboratively-developed ideas in a fast-paced environment.
  • Desired Qualifications
  • Master's degree
  • A strong publication record- they will have the opportunity to assist in the preparation and co-author manuscripts.
  • Underfill Statement

    This position may be underfilled at a lower classification depending on the qualifications of the selected candidate.

    Background Screening

    Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre- employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

    Application Deadline

    Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

    U-M EEO/AA Statement

    The University of Michigan is an equal opportunity/affirmative action employer.

    U-M COVID-19 Vaccination Policy

    COVID-19 vaccinations are now required for all University of Michigan students, faculty and staff across all three campuses, including Michigan Medicine, by the start of the fall term on August 30, 2021. This includes those working or learning remotely. More information on this policy is available on the Campus Blueprint website or the U-M Dearborn and U-M Flint websites.

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