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We are seeking a dedicated individual to join our laboratory team which is
focused on organogenesis of the intestine. The applicant must have a
Bachelor's degree (Master's degree desired) and a minimum of 2 years of
relevant post-baccalaureate experience. Daily duties would include
participating in all aspects of bench-side research (including but not
limited to: human intestinal organoid culture, rodent recovery surgery
including kidney capsule transplantation and osmotic pump placement, mouse
breeding, genotyping, dissections, tissue fixation and processing, confocal
and light microscopy, data recording, image processing, cell culture, tissue
explant culture). Additionally, the individual would take a primary role in
overseeing the management of the mouse colony for the laboratory. This
position may also include mentoring of undergraduate students and oversight of
other lab personnel. The ideal applicant will actively read relevant
literature and participate intellectually as well as technically; co-
authorship on manuscripts is expected where contributions warrant.
The successful candidate should have: outstanding interpersonal skills,
experience working with advanced molecular biology tools and tissue culture
methods, an understanding of human and mouse genetics and use of transgenic
and knock-out mouse lines and experience in mouse breeding and colony
Michigan Medicine improves the health of patients, populations and communities
through excellence in education, patient care, community service, research and
technology development, and through leadership activities in Michigan,
nationally and internationally. Our mission is guided by our Strategic
Principles and has three critical components; patient care, education and
research that together enhance our contribution to society.
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and
has been the site of many groundbreaking medical and technological
advancements since the opening of the U-M Medical School in 1850. Michigan
Medicine is comprised of over 30,000 employees and our vision is to attract,
inspire, and develop outstanding people in medicine, sciences, and healthcare
to become one of the world's most distinguished academic health systems. In
some way, great or small, every person here helps to advance this world-class
institution. Work at Michigan Medicine and become a victor for the greater
What Benefits can you Look Forward to?
Excellent medical, dental and vision coverage effective on your very first
2:1 Match on retirement savings
Laboratory management will include but not be limited to: oversee day-to-day operations of the laboratory, lab supply ordering, personnel scheduling, maintenance of detailed records/procedures, and maintenance of regulatory compliance documentation (5%).
The candidate will actively participate in project planning and coordination of projects with other laboratories (10%).
Oversight of mouse colony maintenance and preparation for experiments including, but not limited to: weaning, placing ear tags, collecting ear punches, genotyping, checking copulatory plugs, oral gavage feeding of tamoxifen, feeding of doxycycline chow and doxycycline water (10%).
DNA/RNA isolation & purification methods, PCR, tissue embedding, vibratome sectioning, paraffin sectioning, frozen sectioning, immunostaining, H&E staining, fluorescent RNA in situ hybridization, brightfield imaging, widefield fluorescence imaging, confocal imaging (35%).
Advanced 3D cell culture of human intestinal organoids including media preparation, changing media, and organoid culture (30%).
Assist in surgical procedures on mice including transplantation of human intestinal organoids under the host kidney capsule and placement of osmotic pumps (5%).
The candidate will assist (co-author) in the preparation of research papers, meeting presentations, and grant proposals (5%).
Bachelor's degree in a relevant field with at least 2 years' experience in
a cellular and molecular biology research lab.
Experience in advanced tissue culture.
Experience in molecular biology tools (DNA/RNA purification, DNA
transfection, qRT-PCR, Western Blot).
Experience in mouse handling and care.
Outstanding interpersonal skills - the applicant must have the ability to
work independently, and in a diverse team environment.
Ability to multi-task, prioritize efforts, and execute independently and
collaboratively-developed ideas in a fast-paced environment.
A strong publication record- they will have the opportunity to assist in
the preparation and co-author manuscripts.
This position may be underfilled at a lower classification depending on the
qualifications of the selected candidate.
Michigan Medicine conducts background screening and pre-employment drug
testing on job candidates upon acceptance of a contingent job offer and may
use a third party administrator to conduct background screenings. Background
screenings are performed in compliance with the Fair Credit Report Act. Pre-
employment drug testing applies to all selected candidates, including new or
additional faculty and staff appointments, as well as transfers from other U-M
Job openings are posted for a minimum of seven calendar days. The review and
selection process may begin as early as the eighth day after posting. This
opening may be removed from posting boards and filled anytime after the
minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action
U-M COVID-19 Vaccination Policy
COVID-19 vaccinations are now required for all University of Michigan
students, faculty and staff across all three campuses, including Michigan
Medicine, by the start of the fall term on August 30, 2021. This includes
those working or learning remotely. More information on this policy is
available on the Campus Blueprint website or the U-M Dearborn and U-M Flint