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A cover letter is required for consideration for this position and should be
attached as the first page of your resume. The cover letter should address
your specific interest in the position and outline skills and experience that
directly relate to this position.
Dr. Lauren Surface's newly established lab in the University of Michigan
School of Dentistry is recruiting postdoctoral research fellows. Research in
the Surface Lab focuses on two main directions, united by similar
methodologies of employing genome-wide approaches followed by molecular and
organismal investigations, to understand the molecular responses of bone
cells. Postdocs are encouraged to pursue research that is of interest to them
that fall within these directions.
As we age, our quality of life critically depends on the skeletal and
craniofacial bones, in both health and disease. The skeleton is not only of
immense clinical importance, notably in the weakening of bones seen in
osteoporosis, but also is a model for studying communication across organs, as
bone cells help to coordinate many aspects of organismal homeostasis,
including phosphate regulation, disruption of which can have major
consequences for health. The research the Surface Lab pursues addresses both
aspects of bone health in aging and disease.
The first direction focuses on the molecular mechanisms of bisphosphonates
(commonly prescribed drugs used to treat osteoporosis). Our long-term goal
is to understand the molecular, cellular, and organismal pathways essential
for the responses to these drugs. Using a CRISPRi screen, we previously
identified over 300 genes that affect the response to bisphosphonates. Two
genes, ATRAID and SLC37A3 , were of particular interest due to the
strength of their effect on BP response, and we found these genes were
essential for the lysosomal release of these drugs. Future studies will aim
to investigate both the function of these proteins, and the larger set of
genes identified as bisphosphonate regulators, and how they determine the
organismal response to these drugs. will build on these studies, in a
variety of directions, to investigate factors that may affect the patient
response to these drugs.
The second direction seeks to identity how cells in bone sense and respond to
changes in serum phosphate concentration, with this response being key in the
endocrine control of mineral ion metabolism. Organismal phosphate (Pi)
homeostasis is tightly controlled to maintain a consistent serum Pi level,
disruption of which can have major consequences for the body. Indeed,
phosphorus is key to the regulation of cellular signaling, enzymatic activity,
metabolic energy, lipid metabolism, as well as muscle, kidney and neurological
functions. How bone cells sense changes in Pi remains an outstanding question
in endocrinology. Using cell-based approaches, include genome-wide CRISPR
screens, our goal is to identify factors in bone cells responsible for sensing
and responding to changes in extracellular Pi concentration, and translate
these findings to understanding organismal Pi homeostasis and overall mineral
Qualifications: The candidate should have a PhD, MD, or DDS in a relevant
field. They should believe in kindness towards others, have an enthusiasm for
learning and asking questions, and an ability to work independently as well as
in a group environment
MDentistry: advancing health through education, service, research and
MDentistry Core Values: Compassion, Leadership, Excellence, Responsibility,
Trust, Creativity, and Inclusion.
The mission of the University of Michigan is to serve the people of Michigan
and the world through preeminence in creating, communicating, preserving and
applying knowledge, art, and academic values, and in developing leaders and
citizens who will challenge the present and enrich the future. The University
of Michigan is committed to foster learning, creativity and productivity, and
to support the vigorous exchange of ideas and information, not only in the
classroom but in the workplace by:
Creating a work environment in which people treat each other with respect
and dignity, regardless of roles, responsibilities or differences.
Providing support, direction and resources enabling us to accomplish the
responsibilities of our jobs and to reach the goals that are set for
professional and personal growth.
This position is located at the School of Dentistry at 1011 N. University
Avenue, Ann Arbor, MI 48109-1078.
The University of Michigan conducts background checks on all job candidates
upon acceptance of a contingent offer and may use a third party administrator
to conduct background checks. Background checks will be performed in
compliance with the Fair Credit Reporting Act.
Job openings are posted for a minimum of seven calendar days. This job may be
removed from posting boards and filled anytime after the minimum posting
period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action
U-M COVID-19 Vaccination Policy
COVID-19 vaccinations are now required for all University of Michigan
students, faculty and staff across all three campuses, including Michigan
Medicine, by the start of the fall term on August 30, 2021. This includes
those working or learning remotely. More information on this policy is
available on the Campus Blueprint website or the U-M Dearborn and U-M Flint