Research Fellow in Structural and Cell & Molecular Virology (2 posts)

University of Leeds

United Kingdom

February 2, 2022

Description

Research Fellow in Structural and Cell & Molecular Virology (2 posts)

Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural biology OR cellular & molecular biology? Do you want to further your career in one of the UKs leading research intensive Universities?

We have established a new paradigm that regulates the assembly of viral particles around ssRNA genomes, including para-retroviruses. RNA Packaging Signal (PS)-mediated Assembly requires cognate interactions to be formed between multiple RNA motifs/sequences across viral genomes (gRNAs). It ensures that genome packaging is specific, explaining the observed outcomes of natural infections. PSs are evolutionarily conserved between strain variants, including coronaviruses, making them excellent anti-viral drug targets. PS- coat contacts form and then mostly break during virion assembly, explaining infection directionality and resulting in particles poised to infect a new host. We are investigating fundamental and applied aspects of virology around this mechanism using a multidisciplinary team, embracing experiment and theory.

Two short-term Postdoctoral Fellowships are now available, until late Spring 2023, in Structural Virology, especially using modern cryo-electron microscopy, and in Cell and Molecular Virology, especially for in vitro & in vivo assembly studies. You should have a PhD (or close to completion) in structural biology, molecular genetics, cell & molecular biology, biochemistry or biophysics or a closely allied discipline. You should also have experience in appropriate technical skills and experience, such as the use of cryo-EM to determine molecular structures, or biophysical techniques to probe molecular interactions; or recombinant protein expression; cell biology for in vivo virological studies. Further grant funding has been sought so the post could be extended in future.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

To explore the post further or for any queries you may have, please contact:

Peter Stockley, Professor

Email: P.G.Stockley@leeds.ac.uk

Location: Leeds - Main Campus

Faculty/Service: Faculty of Biological Sciences School/Institute: School of Molecular & Cellular Biology Category: Research Grade: Grade 7 Salary: £34,304 to £40,927 p.a. Working Time: 100% Post Type: Full Time Contract Type: Fixed Term (available on a fixed-term basis for 12 months due to external funding) Release Date: Wednesday 12 January 2022 Closing Date: Wednesday 02 February 2022 Reference: FBSMB1215 Downloads: Candidate Brief

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About the employer

The University of Leeds is a public research university in Leeds, West Yorkshire, England. It was established in 1874 as the Yorkshire College of Science. In 1884 it merged with the Leeds School of Medicine (established 1831) and was renamed...