Research Fellow in Chemical Biology
Chemical Biology, Diagnostics & Therapeutics
Location: Highfield Campus
Salary: £32,348 to £39,745 per annum
Full Time Fixed Term for 12 months
Closing Date: Tuesday 27 September 2022
Interview Date: To be confirmed
You will join our interdisciplinary project at the interface of Chemical
Biology and Supramolecular Chemistry at the University of Southampton working
with Profs Steve Goldup and Ali Tavassoli.
The project is a collaboration between the Goldup and Tavassoli groups and
aims to use DNA Rotaxanes and Catenanes to control cellular processes.
Rotaxanes, molecules in which a linear component is trapped within a ring-
shaped molecule like a bead on a thread, and catenanes, molecules formed of
two rings threaded through one another like links in a chain, are the
archetypal interlocked molecules. Holding the molecular components together
like this changes their properties considerably and leads to new functions and
applications. Indeed, nature has taken advantage of this approach to stabilise
DNA in catenane structures ( Nature , 1967 , 647) and peptides as
rotaxanes ( Acc. Chem. Res. 2015 , 1909). For an introduction to the
properties of mechanically interlocked molecules see: “ Chemical
consequences of mechanical bonding in catenanes and rotaxanes ” ( Chem.
Commun. 2014 , 5128).
This project builds on recently developed DNA rotaxanes by the Goldup and
Tavassoli Groups ( J. Am. Chem. Soc. 2020 , 5985). You will work in a
multidisciplinary team to use next generation, switchable DNA rotaxanes to
regulate biological processes in mammalian cells. These compounds have the
potential to become novel tools with applications in cell biology for
regulating biological processes.
To be successful you will have a background in multidisciplinary science,
particularly chemical biology and/or cell biology. Experience of working with
mammalian cell culture and associated techniques is highly desirable. You will
also have opportunities to develop your supervisory, written and oral
communication skills, excellent preparation for a career in academia or
industry. As a member of the group you will present your published work at
national and international conferences and funding is available to support
You will be based in the modern chemistry laboratories in the School of
Chemistry at the University of Southampton. Support for synthetic chemistry,
chemical biology and cell biology is excellent with world class, cell culture,
molecular biology, and chemical biology facilities, and as well as MS, NMR and
X-ray facilities, each supported by dedicated specialist staff. For more
Goldup Group: https:// goldup.soton.ac.uk/
Tavassoli Group: https: // www. southampton.ac.uk/chemistry/about/staff/ali1.page
The post will initially be offered for 12 months due to funding restriction
but this may be extended. For additional information please contact Professor
Ali Tavassoli and Professor Steve Goldup by email (email@example.com and S.
At the University of Southampton, we value diversity and equality. The
University recognises that employees may wish to have working patterns that
fit with their caring responsibilities or work-life balance. Due consideration
will also be given to applicants who have had career breaks for reasons
including maternity, paternity or adoption leave, disability or illness. Both
the University of Southampton and Chemistry are proud to hold Athena Swan
Applications for Research Fellow positions will be considered from
candidates six months from completion of a relevant PhD qualification. The
title of Research Fellow will be applied upon successful completion of the
PhD. Prior to the qualification being awarded the title of Senior Research
Assistant will be given.
You should submit your completed online application form at
https: // jobs.soton.ac.uk. The application deadline will be midnight on the
closing date stated above. If you need any assistance, please call Michelle
Jose (HR Recruitment Team) on +44 (0) 23 8059 2750 or email
firstname.lastname@example.org Please quote reference 1954922EB on all
Job Description and Person Specification
We aim to be an equal opportunities employer and welcome applications from all
sections of the community. Please note that applications from agencies will
not be accepted unless indicated in the job advert.