Research Fellow in Cell Biology/Biochemistry

University of Leeds

United Kingdom

September 30, 2022

Description

Research Fellow in Cell Biology/Biochemistry

Are you looking to apply your skills in Biochemistry/Cell Biology to help gain a new molecular understanding of how proteins assemble into amyloid fibrils and help to develop new routes to understand the molecular origins of memory formation and memory loss in disease?

We are looking for a postdoctoral research fellow to join our well-established interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils and cause disease. This Royal Society-funded post-doctoral fellowship aims to determine the mechanisms of amyloid formation in vitro and its effect on cellular homoestasis. You will focus on a range of contrasting proteins, one involved in neurodegeneration (a-synuclein (aSyn) associated with Parkinson's disease), a functional amyloid (CPEB/Orb2, involved in the formation and storage of long-term memories), and a protein involved in systemic amyloid disease (IAPP, associated with type II diabetes). Specifically, you will use biochemical approaches to modify the structures of the protein aggregates and determine their effect on cellular function, using primary cells, cell lines and relevant tissues. In addition, you will investigate how small molecule modulators of amyloid formation that we have recently discovered affect the cellular consequences of amyloid formation. The outcome will be a transformation in our understanding of how amyloid fibrils create or destroy memory, and new opportunities to target the dynamic interactome of amyloid fibril assemblies for human benefit.

You will be based in the laboratory of Professor Sheena Radford. The work will be carried out also in collaboration with Dr Jessica Kwok and Professor Sue Deuchars and Professor Jim Deuchars (School of Biomedical Sciences, University of Leeds).You will have a PhD (or be close to completion) in Cell Biology, Neurobiology, Biochemistry, or a related discipline. You will have experience of measuring cellular function and dysfunction using cell biology and other assays and of working with proteins and protein biochemistry. You will also be able to gain experience and training in other methods as the project develops. Experience in working within the amyloid field or in neurobiology would be an advantage.

Further information about the project and our recent publications are available within the additional information document.

To explore the post further or for any queries you may have, please contact:

Sheena E Radford, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170 Email: s.e.radford@leeds.ac.uk

Location: Leeds - Main Campus

Faculty/Service: Faculty of Biological Sciences School/Institute: Astbury Centre Category: Research Grade: Grade 7 Salary: £35,333 to £42,155 p.a. Working Time: 100% - We are open to discussing flexible working arrangements Post Type: Full Time Contract Type: Fixed Term (for 2 years due to funding) Release Date: Friday 02 September 2022 Closing Date: Friday 30 September 2022 Reference: FBSAC1006 Downloads: Candidate Brief Additional Information

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About the employer

The University of Leeds is a public research university in Leeds, West Yorkshire, England. It was established in 1874 as the Yorkshire College of Science. In 1884 it merged with the Leeds School of Medicine (established 1831) and was renamed...