Research Associate

University of Cambridge
December 11, 2022
Offerd Salary:£34,308-£42,155
Working address:N/A
Contract Type:Fixed-term The funds
Working Time:Negotigation
Working type:N/A
Job Ref.:N/A
Research Associate

The University of Cambridge wishes to appoint a postdoctoral scientist to join the research groups of Prof Patrick Chinnery and Dr Jelle van den Ameele at the Department of Clinical Neurosciences and the MRC Mitochondrial Biology Unit.

The position is part of a collaborative MRC MitoCluster award, within the MRC National Mouse Genetics Network (https: //, to develop and characterise novel mouse models of mitochondrial disease. The focus of your work will be on studying how heteroplasmic mitochondrial DNA (mtDNA) mutations change over time in somatic tissues, during development and aging.

You will use innovative single-cell RNA- and ATAC-sequencing, develop novel library prep and targeted enrichment protocols, and apply these in different mouse strains with novel mtDNA mutations. You will generate cell lines from these mouse strains, and perform in vitro and in vivo forward genetic screening using single-cell CRISPR/Cas9 technology, to identify novel nuclear genetic modifiers of mtDNA mutation burden.

You will have access to a team of experienced bioinformaticians, but will be encouraged and trained to perform independent in-depth bioinformatic analysis of large single-cell seq datasets. You will have access to clinical samples, to apply and translate novel technology and insights towards a human disease context.

You will drive the project within the laboratory, together with both group leaders and in close interaction with other members of the MRC MitoCluster. As a member of our research groups, you will participate in group meetings and internal seminars. You will assist in supervision of junior lab members. You will be encouraged to apply for external funding and receive support to undertake further training and career development.

Candidates are expected to be independent, highly motivated, and keen to work collaboratively with internal and external scientists. You will demonstrate core values of the labs, which include enthusiasm, openness and integrity. A PhD in molecular biology, biochemistry, genetics or a related field is required. You will have a publication track record, with a good, peer-reviewed first author paper, either published or in press. Ideal qualifications include experience with single-cell library preparation and analysis, advanced molecular biology techniques, and CRISPR/Cas9 screening, but others are welcome to apply.

The position offers a competitive salary and enjoys the diverse and highly interactive research environment of the world-renowned Mitochondrial Biology Unit and Department of Clinical Neurosciences at the Cambridge Biomedical Campus, and the broad network of the MRC NMGN collaborators.

The lab and the wider University of Cambridge are committed, in their pursuit of academic and research excellence, to a pro-active and inclusive approach to equality, which supports and encourages all under-represented groups, promotes an inclusive culture, and values diversity. Flexible working and working from home arrangements are available. The University particularly encourages women and candidates from Black, Asian and Minority Ethnic backgrounds to apply.

Lab websites: MRC MBU Research groups: https: // www. groups Cambridge Clinical Mitochondrial Research team: https: // www- MRC MitoCluster: https: //

Fixed-term: The funds for this post are available until 13th October 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date: 11th December 2022

Date of interview: To be confirmed

Please quote reference ZE34337 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information
  • Further Particulars
  • Department/Location

    Department of Clinical Neurosciences








    23 November 2022

    Closing date

    11 December 2022

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