Research Associate

University of Glassgow

United Kingdom

November 4, 2021


Research Associate

Job Purpose

To make a leading contribution to the project ‘ Mitochondrial redox protein quality control in ageing' , working with PI Professor Kostas Tokatlidis and in collaboration with the Co-I Prof Alberto Sanz at the IMCSB/MVLS.

Specifically, the postholder will conduct, manage and publish research in the area of mitochondria biology with the aim to elucidate the redox protein quality control processes in mitochondria and how they impact the ageing process.

This knowledge is missing and is a prerequisite to fully understand how mitochondria can maintain a healthy redox balance that is critical for cell survival and stress resistance. This requires a knowledge of both oxidative and reductive pathways and an interplay of these with mitochondrial ROS (mtROS) to preserve mitochondrial fitness in response to deleterious stresses and metabolic alterations. The specific objectives of the project are (1) to dissect the reductive machinery operating in the IMS and analyse its effects on folded protein retention in the IMS or retrograde export and degradation (2) to dissect the effects of the redox machinery on the global IMS redox state and mitochondrial metabolite transport in signalling processes (3) to investigate the redox protein quality control as a key determinant in organismal ageing using Drosophila. The postholder will also assist in managing, directing and developing this complex and challenging project.

Main Duties and Responsibilities

Perform the following activities in conjunction with the Principal Investigator (PI): 1. Take a leading role in the planning and conduct of assigned research individually or jointly in accordance with the project deliverables and project/group/IMCSB/MVLS College research strategy. 2. Document research output including analysis and interpretation of all data, maintaining records and databases, drafting technical/progress reports and papers as appropriate. 3. Establish and maintain your research profile and reputation and that of the MCSB and the PI group including establishing and sustaining a track record of independent and joint publications of international quality in high profile/quality refereed journals and conferences, enhancing the research impact in terms of economic/societal benefit, and gathering indicators of esteem. 4. Survey the research literature and environment, understand the research challenges associated with the project & subject area, & develop/implement a suitable research strategy. 5. Presentation of work at international and national conferences, at internal and external seminars, colloquia and workshops to develop and enhance our research profile. 6. Take a leading role in the identification of potential funding sources and to assist in the development of proposals to secure funding from internal and external bodies to support future research. 7. Take a leading role in developing and maintaining collaborations with colleagues across the research within IMCSB and CMVLS, chemical biology groups in the School of Chemistry, and relevant groups in bioengineering within the College of Science and Engineering, and the wider community (eg academic and Industrial Partners). 8. Take a leading role in team/group meetings/seminars/workshops and Institute research group activities to enhance the wider knowledge, outputs and culture of the IMCSB/CMVLS. 9. Take the lead in the organisation, supervision, mentoring and training of undergraduate and/or postgraduate students and less experienced members of the project team to ensure their effective development. 10. Perform administrative tasks related to the activities of the research group and Institute, including budgets/expenditure. 11. Make a leading contribution to outreach and recruitment activities of the University of Glasgow. 12. Make a leading contribution to teaching activities (e.g. demonstrating, lecture delivery, tutorials, etc) and associated administration as assigned by the PI and in consultation with the Director of the Institute. 13. Be responsible for safety management related to the organisation and running of laboratory and/or experimental techniques, equipment and processes as appropriate. 14. Keep up to date with current knowledge and recent advances in the field/discipline. 15. Engage in personal, professional and career development, to enhance both specialist and transferable skills in accordance with desired career trajectory. 16. To contribute to the enhancement of the University's international profile in line with the University's Strategic Plan - Inspiring People – Changing the World. https:// www. 17. Undertake any other duties of equivalent standing as assigned by the PI.

These key tasks are not intended to be exhaustive but simply highlight a number of major tasks which the staff member may be reasonably expected to perform.

Knowledge, Qualifications, Skills and Experience



A1. Normally Scottish Credit and Qualification Framework level 12 (PhD) in Life Sciences or a related field or alternatively possess the equivalent in professional qualifications and experience, with experience of personal development in a similar or related role. A2. Strong ambition, commitment and drive for a research career.

A3. Extensive and up-to-date theoretical and practical knowledge in areas related to the field of research. A4. Understanding of relevant health and safety policies and procedures relative to the role.

A5. Knowledge of mitochondrial biology, redox biology and ageing


B1. Knowledge of mitochondrial dynamics, protein targeting and folding. B2. Knowledge of chemical/small molecule probes in cellular processes or molecular pharmacology.

B3. Understanding of Intellectual Property protection.



C1. Extensive research skills in biochemistry and molecular cell biology including analysis of protein-protein interactions (yeast or mammalian cell culture or Drosophila, FRET or protein-complementation assays), epitope tagging and pull-down assays

C2. Experience in use of fluorescent probes for organelle analysis and/or ROS detection

C3. Research creativity and strong cross-discipline collaborative ability as appropriate.

C4. Highly motivated, ability to use initiative and quick to learn new techniques. C5. Excellent communication skills (oral and written), including public presentations and ability to communicate complex/specialist concepts clearly and concisely.

C6. Excellent interpersonal skills including team working and a collegiate approach and aptitude to work in a multidisciplinary environment. C7. Appropriate workload and time management skills.

C8. Extensive IT and data analysis/interpretation skills as appropriate. C9. Problem solving skills including a flexible and pragmatic approach.

C10. Good team leadership skills including demonstrable supervisory skills.


D1. Mitochondrial assays (import, functionality, ROS measurement) and redox assays (thiol state analysis by mass spectrometry or gel shift assays) D2. Protein-protein interactions in vivo and in vitro.

D3. Drosophila genetics, knockdown and phenotypic assays in flies.



E1. Sufficient breadth and/or depth of knowledge in specialist subject/discipline and of research/teaching methods and techniques relevant to project subject area, demonstrated through relevant post-doctoral experience. E2. Experience of research in any aspect or combination of mitochondrial biology, intracellular protein trafficking, organelle biology, protein biochemistry (protein targeting, modification, folding, biophysical analysis) or chemical/redox biology and ageing.

E3. Experience of scientific writing, leading the drafting of research papers. E4. Proven ability to deliver quality outputs in a timely and efficient manner.

E5. A track record of presentation and publication of research results in quality journals/conferences. E6. Experience of making a leading contribution in academic activities.

E7. Ability to demonstrate a degree of independence as illustrated by identification of project objectives from assessment of the literature, design & analysis of experiments & drafting of papers. E8. Experience in undertaking independent research.


F1. An emerging national or international reputation. F2. Potential in developing key research questions into tractable experimental methodology.

Terms and Conditions

Salary will be on the University's Research and Teaching Grade 7, £36,382 - £40,927 per annum.

This post is fixed term until 30.1.25.

Relocation assistance may be provided where appropriate.

New entrants to the University will be required to serve a probationary period of 6 months.

The successful applicant will be eligible to join the Universities' Superannuation Scheme. Further information regarding the scheme is available from the Superannuation Officer, who is also prepared to advise on questions relating to the transfer of Superannuation benefits.

It is the University of Glasgow's mission to foster an inclusive climate, which ensures equality in our working, learning, research and teaching environment.

We strongly endorse the principles of Athena SWAN, including a supportive and flexible working environment, with commitment from all levels of the organisation in promoting gender equality.

The University of Glasgow, charity number SC004401.

Vacancy Reference: 069607, Closing Date: 4 November 2021

Vacancy Ref : 069607 Close Date : 04-Nov-2021 23:45

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