To make a leading contribution to the project ‘ Mitochondrial redox protein
quality control in ageing' , working with PI Professor Kostas Tokatlidis and
in collaboration with the Co-I Prof Alberto Sanz at the IMCSB/MVLS.
Specifically, the postholder will conduct, manage and publish research in the
area of mitochondria biology with the aim to elucidate the redox protein
quality control processes in mitochondria and how they impact the ageing
This knowledge is missing and is a prerequisite to fully understand how
mitochondria can maintain a healthy redox balance that is critical for cell
survival and stress resistance. This requires a knowledge of both oxidative
and reductive pathways and an interplay of these with mitochondrial ROS
(mtROS) to preserve mitochondrial fitness in response to deleterious
stresses and metabolic alterations. The specific objectives of the project are
(1) to dissect the reductive machinery operating in the IMS and analyse its
effects on folded protein retention in the IMS or retrograde export and
degradation (2) to dissect the effects of the redox machinery on the global
IMS redox state and mitochondrial metabolite transport in signalling processes
(3) to investigate the redox protein quality control as a key determinant in
organismal ageing using Drosophila. The postholder will also assist in
managing, directing and developing this complex and challenging project.
Main Duties and Responsibilities
Perform the following activities in conjunction with the Principal
1. Take a leading role in the planning and conduct of assigned research
individually or jointly in accordance with the project deliverables and
project/group/IMCSB/MVLS College research strategy.
2. Document research output including analysis and interpretation of all
data, maintaining records and databases, drafting technical/progress reports
and papers as appropriate.
3. Establish and maintain your research profile and reputation and that of
the MCSB and the PI group including establishing and sustaining a track record
of independent and joint publications of international quality in high
profile/quality refereed journals and conferences, enhancing the research
impact in terms of economic/societal benefit, and gathering indicators of
4. Survey the research literature and environment, understand the research
challenges associated with the project & subject area, & develop/implement a
suitable research strategy.
5. Presentation of work at international and national conferences, at
internal and external seminars, colloquia and workshops to develop and enhance
our research profile.
6. Take a leading role in the identification of potential funding sources and
to assist in the development of proposals to secure funding from internal and
external bodies to support future research.
7. Take a leading role in developing and maintaining collaborations with
colleagues across the research within IMCSB and CMVLS, chemical biology groups
in the School of Chemistry, and relevant groups in bioengineering within the
College of Science and Engineering, and the wider community (eg academic and
8. Take a leading role in team/group meetings/seminars/workshops and
Institute research group activities to enhance the wider knowledge, outputs
and culture of the IMCSB/CMVLS.
9. Take the lead in the organisation, supervision, mentoring and training of
undergraduate and/or postgraduate students and less experienced members of the
project team to ensure their effective development.
10. Perform administrative tasks related to the activities of the research
group and Institute, including budgets/expenditure.
11. Make a leading contribution to outreach and recruitment activities of the
University of Glasgow.
12. Make a leading contribution to teaching activities (e.g. demonstrating,
lecture delivery, tutorials, etc) and associated administration as assigned
by the PI and in consultation with the Director of the Institute.
13. Be responsible for safety management related to the organisation and
running of laboratory and/or experimental techniques, equipment and processes
14. Keep up to date with current knowledge and recent advances in the
15. Engage in personal, professional and career development, to enhance both
specialist and transferable skills in accordance with desired career
16. To contribute to the enhancement of the University's international
profile in line with the University's Strategic Plan - Inspiring People –
Changing the World. https:// www. gla.ac.uk/about/strategy/people/
17. Undertake any other duties of equivalent standing as assigned by the PI.
These key tasks are not intended to be exhaustive but simply highlight a
number of major tasks which the staff member may be reasonably expected to
Knowledge, Qualifications, Skills and Experience
A1. Normally Scottish Credit and Qualification Framework level 12 (PhD) in
Life Sciences or a related field or alternatively possess the equivalent in
professional qualifications and experience, with experience of personal
development in a similar or related role.
A2. Strong ambition, commitment and drive for a research career.
A3. Extensive and up-to-date theoretical and practical knowledge in areas
related to the field of research.
A4. Understanding of relevant health and safety policies and procedures
relative to the role.
A5. Knowledge of mitochondrial biology, redox biology and ageing
B1. Knowledge of mitochondrial dynamics, protein targeting and folding.
B2. Knowledge of chemical/small molecule probes in cellular processes or
B3. Understanding of Intellectual Property protection.
C1. Extensive research skills in biochemistry and molecular cell biology
including analysis of protein-protein interactions (yeast or mammalian cell
culture or Drosophila, FRET or protein-complementation assays), epitope
tagging and pull-down assays
C2. Experience in use of fluorescent probes for organelle analysis and/or ROS
C3. Research creativity and strong cross-discipline collaborative ability as
C4. Highly motivated, ability to use initiative and quick to learn new
C5. Excellent communication skills (oral and written), including public
presentations and ability to communicate complex/specialist concepts clearly
C6. Excellent interpersonal skills including team working and a collegiate
approach and aptitude to work in a multidisciplinary environment.
C7. Appropriate workload and time management skills.
C8. Extensive IT and data analysis/interpretation skills as appropriate.
C9. Problem solving skills including a flexible and pragmatic approach.
C10. Good team leadership skills including demonstrable supervisory skills.
D1. Mitochondrial assays (import, functionality, ROS measurement) and redox
assays (thiol state analysis by mass spectrometry or gel shift assays)
D2. Protein-protein interactions in vivo and in vitro.
D3. Drosophila genetics, knockdown and phenotypic assays in flies.
E1. Sufficient breadth and/or depth of knowledge in specialist
subject/discipline and of research/teaching methods and techniques relevant to
project subject area, demonstrated through relevant post-doctoral experience.
E2. Experience of research in any aspect or combination of mitochondrial
biology, intracellular protein trafficking, organelle biology, protein
biochemistry (protein targeting, modification, folding, biophysical
analysis) or chemical/redox biology and ageing.
E3. Experience of scientific writing, leading the drafting of research papers.
E4. Proven ability to deliver quality outputs in a timely and efficient
E5. A track record of presentation and publication of research results in
E6. Experience of making a leading contribution in academic activities.
E7. Ability to demonstrate a degree of independence as illustrated by
identification of project objectives from assessment of the literature, design
& analysis of experiments & drafting of papers.
E8. Experience in undertaking independent research.
F1. An emerging national or international reputation.
F2. Potential in developing key research questions into tractable experimental
Terms and Conditions
Salary will be on the University's Research and Teaching Grade 7, £36,382 -
£40,927 per annum.
This post is fixed term until 30.1.25.
Relocation assistance may be provided where appropriate.
New entrants to the University will be required to serve a probationary period
of 6 months.
The successful applicant will be eligible to join the Universities'
Superannuation Scheme. Further information regarding the scheme is available
from the Superannuation Officer, who is also prepared to advise on questions
relating to the transfer of Superannuation benefits.
It is the University of Glasgow's mission to foster an inclusive climate,
which ensures equality in our working, learning, research and teaching
We strongly endorse the principles of Athena SWAN, including a supportive and
flexible working environment, with commitment from all levels of the
organisation in promoting gender equality.
The University of Glasgow, charity number SC004401.
Vacancy Reference: 069607, Closing Date: 4 November 2021
Vacancy Ref : 069607 Close Date : 04-Nov-2021 23:45