Research Associate / Senior Research Associate (Computational Biologist) (Fixed Term)

University of Cambridge

United Kingdom

June 9, 2022

Description

Research Associate / Senior Research Associate (Computational Biologist)

(Fixed Term)

We are recruiting a Research Associate / Senior Research Associate (Computational Biologist) to join the Systems Cancer Pathology group at the CRUK Cambridge Institute, led by Dr Raza Ali. We are a leading group in high dimensional single cell spatial proteomics (imaging mass cytometry) in cancer (1,2). The role involves working as part of a diverse team including pathologists, oncologists, cancer biologists and computational biologists.+

The candidate should hold a PhD in a quantitative discipline (e.g. computer science, computational biology), but candidates with a PhD in immunology/cancer biology with strong computational expertise are also encouraged to apply. You should be highly motivated with an interest in high dimensional imaging data and developing new quantitative methods to assess the spatial dynamics of cancer cells and the tumour microenvironment in patient samples. You will work with Dr Raza Ali, group leader and academic pathologist. Ours is a young team, combining wet and dry lab.

Our aim is to understand how the tumour microenvironment coevolves with cancer cells in response to treatment to drive disease relapse and resistance, primarily in breast cancer. We are assembling imaging datasets of unprecedented depth and size in both observational studies and clinical trials. This will enable us to unmask spatial phenotypic traits that emerge during disease progression and treatment, and to identify those that drive prognosis and therapeutic response. The successful candidate will lead the analysis of a large breast cancer study encompassing thousands of samples to understand organisation of the tumour microenvironment and evolution throughout treatment, its implications for clinical outcome as well as its relationship to cancer genetics. A key aim will be to develop the data into an accessible resource that can be visualised and readily interrogated by the wider scientific community.

We offer extensive training in tissue pathology, statistical methods for linking clinical data, analysis of imaging mass cytometry data, as well as the unique opportunity to tackle these novel data and help set analytic standards. Single cell spatial proteomics is a fast-developing field, and there will be ample opportunity to develop new independent research arcs that complement ongoing studies, including developing software for novel workflows and integration with complementary modalities. The institute is equipped with dedicated infrastructure for distributed computation (of which our existing workflows take full advantage) allowing for rapid, scalable analysis of burgeoning multiplexed tissue imaging data.

Informal enquiries are welcomed and should be directed to Dr Raza Ali at Raza.Ali@cruk.cam.ac.uk.

Appointment to Senior Research Associate is subject to approval by the Faculty Board of Clinical Medicine.

Fixed-term: The funds for this post are available for 3 years in the first instance. This post will be funded by Breast Cancer Now.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Our publications

1 Ali, H. R. et al. Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer. Nature Cancer 1, 163-175, doi:10.1038/s43018-020-0026-6 (2020). 2 Danenberg, E. et al. Breast tumor microenvironment structures are associated with genomic features and clinical outcome. Nature genetics, doi:10.1038/s41588-022-01041-y (2022).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 9th June 2022.

Interview Date: TBC.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please quote reference SW31112 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information
  • Further Particulars
  • Department/Location

    Cancer Research UK Cambridge Institute

    Salary

    £33,309 - £40,927 or £42,149 to £53,348

    Reference

    SW31112

    Category

    Research

    Published

    28 April 2022

    Closing date

    9 June 2022

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