Research Associate - Mechanochemistry in biology (Fixed Term)
Fixed-term: The funds for this post are available for 36 months in the first
Applications are invited for a post-doctoral research associate to join the
group of Professor Melinda Duer at the Department of Chemistry on a research
project to understand how cell biology is affected by mechanical strain in
intact in vitro and in vivo tissues. The Duer group is a vibrant, highly
interdisciplinary team with dedicated, well-equipped biological chemistry
laboratories and state-of-the-art molecular characterization facilities.
The project will explore how strain in the extracellular matrix (ECM)
generates chemistry in the ECM proteins and glycans and will assess how
products of this matrix chemistry influence cell differentiation, adhesion and
migration in fibroblastic and cancer cell lines. The successful applicant will
be expected to develop in vitro tissue models suitable for tensile strain
experiments. They will characterize the protein composition and collagen post-
translational modifications of these and ex vivo tissues with proteomics, LC-
MS, confocal and Raman imaging and they will have opportunites to be trained
in any of these methods that they do not already have experience in. They will
perform cell proteomics and qRT-PCR to assess cell differentiation, and they
will have the opportunity to participate in NMR characterization of tissues.
They will be encouraged also to pursue their own development of other
complementary characterization methods applicable to the project goals. They
will work as part of a highly interdisciplary, cohesive team that works
together closely and will co-supervise one or more PhD students on the
Applicants should have (or be about to obtain) a PhD in cell biology,
biophysics, biochemistry, chemistry, biomaterials, or other relevant
discipline. Experience of mammalian cell culture, including use of e.g. siRNA,
inhibitors and/ or CRISPR/Cas9 methods to alter the cell proteome in vitro is
essential. A strong track record in at least one aspect of characterizating
biological tissues is very highly desirable, e.g. confocal or Raman imaging,
NMR spectroscopy, proteomics, LC/MS or similar; method development in any of
these techniques would be an advantage. They will have good data management
and organizational skills and demonstrate a clear enthusiasm for their work.
Demonstrated ability to work in a team is highly desirable; the desire to work
as part of a close-knit team, sharing data and ideas and working together on
complex experiments, is essential.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Please ensure that you upload your Curriculum Vitae (CV), a covering letter
and publication list in the Upload section of the online application. If you
upload any additional documents that have not been requested, we will not be
able to consider these as part of your application.
For queries relating to your application or the application process, please
contact Professor Melinda Duer (email: firstname.lastname@example.org).
Please quote reference MA31789 on your application and in any correspondence
about this vacancy.
The Department holds an Athena SWAN silver award for women in science,
technology, engineering, maths and medicine.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Yusuf Hamied Department of Chemistry
£27,116 - £31,406
or £33,309 - £40,927
16 June 2022
4 August 2022