Research Associate (Fixed Term)

University of Cambridge

United Kingdom

September 25, 2022


Research Associate (Fixed Term)

Research Associate CRUK Cambridge Institute Grade 7 £34,308 to £42,155 dependent on experience 3 years fixed term contract

The Biffi Laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire an experienced and motivated Research Associate (post-doctoral level) with a background in cancer research and strong skills in cell biology, tissue culture, and mouse work to join a team working on studying and targeting cancer-associated cachexia and the tumour microenvironment of pancreatic cancer. The team combines ex vivo human and murine pancreatic tumour organoid/fibroblast co-cultures with murine in vivo models to study and target the interactions between pancreatic cancer cells and the surrounding microenvironment. Common techniques used in the laboratory are generation of orthotopic transplantation models of pancreatic cancer, flow cytometry and sorting, single-cell and bulk RNA-sequencing, multiplexed immunohistochemistry, RNA in situ hybridization, microscopy, drug and CRISPR strategies in both organoids and fibroblasts, pre-clinical studies in genetically engineered mouse models of pancreatic cancer, and analysis of human pancreatic tissues.

The CRUK Cambridge Institute provides cutting-edge scientific infrastructure and expertise. The successful candidate will have access to our world class core facilities and laboratory resources. The prospective candidate will lead a developing project in the lab to characterize the roles of distinct fibroblast subtypes in respect to cancer-associated cachexia using genetically engineered mouse models. It is expected that, as a post-doctoral member of the group, the successful candidate will have a significant input over the direction of its own project, and will contribute with its original and innovative ideas. The candidate should be about to or have received a PhD in a relevant discipline. They should have a strong background in molecular biology and cell biology, with prior knowledge of tissue culture techniques, mouse work and models of cancer. Prior knowledge/expertise in immunology, pancreatic cancer and/or cancer-associated cachexia is desirable. Expertise in data analysis (e.g. analysis of bulk and single-cell RNA sequencing) is also desirable.

Candidates are expected to work effectively as part of a diverse and inclusive team, to be highly collaborative, good communicators and creative thinkers, able to find solutions to problems and contribute intellectually to other projects. For up-to-date information about the research group, please see our websites at: https: // www. https: //

Fixed-term: the funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW32976 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information
  • Further Particulars
  • Department/Location

    Cancer Research UK Cambridge Institute, Cambridge








    1 September 2022

    Closing date

    25 September 2022

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