Research Associate (Fixed Term)
We are looking for a highly motivated, proactive and enthusiastic postdoc to
work on a BBSRC funded project within the recently founded Galliano Laboratory
(https: // gallianolab.org) in the Department of Physiology, Development and
Neuroscience. This project aims to elucidate the role of morphologically and
developmentally diverse dopaminergic neurons in olfactory processing.
This project will combine timed stereotaxic injections of opto- and
chemogenetic effectors and automated olfactory behavioural testing with whole-
cell electrophysiology. By integrating these approaches, you will provide a
multi-level synthesis of how developmentally-defined neurons of the same class
differentially contribute to sensory processing.
Your key role will be to optimise, validate and employ our newly-built and
fully-automated apparatus inspired by the Schaefer's laboratory's
"AutonoMouse". This cage enables high-throughput, self-initiated training of
large cohorts of mice, while providing detailed quantitative data on how
individual animals learn to interact with a range of sensory stimuli. You will
perform stereotaxic injections of chemogenetic tools to manipulate
developmentally distinct populations and DA neurons, design and supervise
behavioural experiments in the AutonoMouse, and develop analysis pipelines for
the large datasets generated by the automated testing. In parallel, you will
be trained to perform whole-cell patch-clamp experiments in olfactory bulb
acute slices carrying opsins and fluorescent indicators. Working closely with
one of the lab's PhD students on this aspect of the project, you will combine
electrophysiology and optogenetics to probe the connectivity of the
developmentally distinct DA populations.
The successful candidate will have, or be about to receive, a PhD in
Neuroscience or a related discipline. They will have technical expertise with
behavioural neuroscience, ideally including test and apparatus design, animal
handling, stereotaxic surgery for opto- or chemo-genetic manipulations; be
experienced in data analysis; and able to demonstrate that they have led a
complex project to completion. Please refer to the further particulars for a
full list of skills.
Appointments will be made on a fixed-term, full-time basis for 3 years in the
first instance. We are open to discuss different patterns of part-time work
that could better suit individual circumstances and/or caring
responsibilities. The start date is flexible, but ideally January 2023.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Candidates should upload a CV (max 3 pages) and a motivation letter
detailing (a) why you want to be part of our lab and lead this project,
(b) how this post will be a good stepping stone for your career, (c) and
which are, in your opinion, the most interesting and yet unanswered question
in the fields of olfaction/adult neurogenesis/neuronal heterogeneity. Please
include the contact details of two professional referees. The application
deadline is 16 October, and we aim to hold interviews between 22 October and 2
Please quote reference PM32700 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society. The Department of
Physiology, Development & Neuroscience particularly encourages women and
candidates from a Black, Asian or Minority Ethnic background to apply for this
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Department of Physiology, Development and Neuroscience
12 August 2022
16 October 2022