Research Associate/Fellow (Fixed term)
Tuesday, 12th October 2021
£27511 to £40322 per annum (pro rata if applicable) depending on skills and experience (minimum £30942 with relevant PhD). Salary progression beyond this scale is subject to performance
A position is open for a talented, proactive postdoctoral researcher to work
on an exciting project funded by Animal Free Research UK. The project will use
human induced pluripotent stem cells differentiated into cardiovascular
lineages (cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells)
to address fibrosis. Indeed, too much growth of fibrotic cells is linked to
half of all diseases in the developed world and often relies on animals
models, which show poor representation to the human condition
This post will be based in Nottingham but will collaborate extensively with
academic colleagues in Birmingham and East Anglia, and industrialists at
AstraZeneca and GlaxoSmithKline. The project will ask: 1) Can cardiac
fibroblast behaviour be controlled? 2) How do cardiac fibroblasts affect
cardiomyocyte function? 3) How are behaviours changed when cells carry
mutations that affect heart function, such as hypertrophic cardiomyopathy? 4)
Are there benefits from putative anti-fibrotic drugs?
The successful candidate for this post will be nearing completion, or will
have completed, a PhD in the biological sciences or equivalent. They will
combine excellence in research, collaboration, communication and meeting
deadlines with a ‘can-do' positive, solution-focussed attitude. The skillsets
the candidate will have or will learn quickly will include the ability to
culture human pluripotent stem cells and direct their differentiation to
cardiovascular lineages. The candidate will have or will gain advanced skills
in functional analysis. As examples, immunostaining, flow cytometry, qPCR etc,
supported by confocal microscopy and macro writing; formation of mono-cultures
or co-cultures in 2D and 3D, including engineered heart tissue for phenotypic
analysis; use of phenotyping approaches, ranging from DNA or RNA analyses or
western blot, through to functional assays such as metabolism, cAMP,
viability, electrophysiology, calcium flux and contractility. These assays
will be used to evaluate the impact of genetic and/or drug challenge to
Full details are in the job specification.
This full time (36.25 hour) post will be offered on a fixed-term contract
until 1st April 2024, with a start date of approximately 1st November 2021.
Job share arrangements may be considered.
Informal enquiries may be addressed to Chris Denning, tel: +44 (0) 115 82
31236 or email email@example.com.
Please note that applications sent directly to this email address will not be
Our University has always been a supportive, inclusive, caring and positive
community. We warmly welcome those of different cultures, ethnicities and
beliefs – indeed this very diversity is vital to our success, it is
fundamental to our values and enriches life on campus. We welcome applications
from UK, Europe and from across the globe. For more information on the support
we offer our international colleagues, see our Moving to Nottingham pages.
For successful international applicants, we provide financial support for your
visa and the immigration health surcharge, plus an interest-free loan to help
cover the cost of immigration-related expenses for any dependants accompanying
you to the UK. For more information please see the our webpage on Financial
support for visas and the immigration health surcharge.
Job Description/Role Profile
Information for candidates ( pdf doc )