Research Associate - Bioinformatician (Fixed Term)

University of Cambridge

United Kingdom

July 7, 2021

Description

Research Associate - Bioinformatician (Fixed Term)

Key words: Acute myeloid leukaemia, lymphoma, tumour evolution, haematopoiesis, single cell transcriptomics and accessibility, 3D genome topology, informatic analysis

We are seeking an enthusiastic and ambitious Research Associate - Bioinformatician to join the group of Professor Brian Huntly based in the University of Cambridge Department of Haematology and Wellcome - MRC Cambridge Stem Cell Institute (CSCI) (https: // www. stemcells.cam.ac.uk/people/pi/huntly). Our group studies the mechanisms of transcriptional and epigenetic dysregulation that drive leukaemia and lymphoma and how these programmes are subverted from their normal role in haematopoietic stem cells and their subsequent progeny. We combine functional and genomic experiments in experimental model systems and patient samples to define normal and pathological mechanisms, identify therapeutic targets and characterise novel therapies (e.g. Sasca et al, Blood 2019, Gozdecka et al, Nature Genetics 2018, Horton et al Nat Cell Biol 2017). We are based in the University of Cambridge's new £94m flagship Jeffrey Cheah Biomedical Centre, with purpose-built lab and bioinformatics space, including the substantial CSCI Bioinformatics Core. We are a well-established multi- disciplinary lab with substantial grant funding (e.g. a CRUK Programme Grant which funds this post) and dedicated bioinformatics and animal support positions and our own, recently upgraded, servers. We are a highly productive, internationally recognised group and enjoy collaborations both within Cambridge and beyond.

Your work will involve analysis of a wide range of genomic data, including ChIP-Seq, scRNA-Seq, bulk and scATAC-Seq, promoter-based capture Hi-C and a new technique, direct capture Perturb-Seq, that we are establishing in our lab. You will need to work with single cell and bulk transcriptomics, 3D DNA- DNA interaction and transcriptional/epigenetic/cis-regulatory network modelling. Your role in the group is highly valued and you will work closely with lab-based researchers and other bioinformaticians to ensure the quality of our data and its analysis.

You will have a PhD, or equivalent experience, in a relevant discipline. You will have experience of developing or adapting computational pipelines and developing your own bioinformatic tools. Experience with analysis of relevant genomic data, relevant sc-techniques and previous work in haematopoieis and/or leukaemia/cancer biology are highly desirable.

Informal enquiries should be addressed to Professor Brian Huntly at bjpb@cam.ac.uk.

Fixed-term: The funds for this post are available until 30 September 2023 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 7th July Interview date: week commencing 19th July

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference RB26935 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information
  • Further Particulars
  • Department/Location

    Department of Haematology

    Salary

    £32,816-£40,322

    Reference

    RB26935

    Category

    Research

    Published

    8 June 2021

    Closing date

    7 July 2021

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