Research Associate/Assistant (Fixed Term)
Applications are invited for a full-time post-doctoral position to develop
functional nanoparticles. The project will build nanoparticle-based biological
reactors capable of concentrating targets and effectors to accelerate
intracellular reactions. The properties of the nanoparticles (size, shape,
intrinsic structure, ligand functionalisation) will be manipulated to control
the proximity effect, and the reactors so-designed will drive target protein
degradation via the ubiquitin-proteasome system as well as lysosomal pathways.
The post is associated with an EPSRC-funded research programme on Next-
generation Biomimetic Nanomedicines. The position is between the protein
engineering lab of Prof Laura Itzhaki (Department of Pharmacology) and the
bionano engineering and nanomaterials design lab of Prof Ljiljana Fruk
(Department of Chemical Engineering and Biotechnology) at Cambridge. The
project will use chemical techniques to assemble and functionalise the
nanoparticles with ligands (peptides, nucleotides, small molecules) and cell
biology techniques to characterise the nanoparticle properties and activities
in mammalian cells.
Applicants should have a first degree or PhD in chemistry, materials science
or in an area relevant to the project. The key duties and responsibilities
will include but are not limited to: developing research objectives and
conducting the research project, continually updating knowledge and
understanding in the field, translating knowledge and advances the research
activity; supporting research activities and communication through
participation at group meetings/seminars; contributing to the supervision of
junior researchers and PhD students and acting as a mentor to less experienced
colleagues; writing up research work for publication; dissemination of
research results by presentation at national and international meetings.
The successful candidate will have experience in nanomaterial preparation and
biofunctionalisation, and organic synthesis with emphasis on click chemistry.
Experience in the field of nanomaterials and drug delivery is desired but not
essential. Some experience with cell-based work is desirable but not
essential. Excellent writing and presentation skills are required, along with
the ability to develop and drive research objectives. It is expected that the
candidate will contribute substantially to the future direction of the
The funds for this post are available for 36 months. The salary range if
appointed as a Research Associate is Grade 7 - £33,309-£40,927 per annum, and
the salary range if appointed as Research Assistant is Grade 5 -
£27,116-£31,406 annum with promotion to Research Associate on attainment of
PhD if applicable.
Fixed-term: The funds for this post are available for 36 months in the first
Starting date: 01/11/2022 or as soon as possible after
The two departments hold Athena SWAN bronze awards, demonstrating a commitment
to provide equal opportunities and to advance the representation of women in
science subjects. We welcome applications from all qualified candidates
irrespective of gender but, as women are currently under-represented at this
level in our department, we strongly encourage applications from female
candidates. Appointment will be based on merit alone.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Informal enquiries about the position can be made to Prof Laura Itzhaki
(email@example.com) or Prof Ljiljana Fruk (firstname.lastname@example.org).
Please quote reference PL32743 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Department of Pharmacology, Department of Chemical Engineering and
Biotechnology, Central Cambridge
15 August 2022
25 September 2022