Research Associate/Assistant (Fixed Term)

University of Cambridge

United Kingdom

September 25, 2022

Description

Research Associate/Assistant (Fixed Term)

Applications are invited for a full-time post-doctoral position to develop functional nanoparticles. The project will build nanoparticle-based biological reactors capable of concentrating targets and effectors to accelerate intracellular reactions. The properties of the nanoparticles (size, shape, intrinsic structure, ligand functionalisation) will be manipulated to control the proximity effect, and the reactors so-designed will drive target protein degradation via the ubiquitin-proteasome system as well as lysosomal pathways.

The post is associated with an EPSRC-funded research programme on Next- generation Biomimetic Nanomedicines. The position is between the protein engineering lab of Prof Laura Itzhaki (Department of Pharmacology) and the bionano engineering and nanomaterials design lab of Prof Ljiljana Fruk (Department of Chemical Engineering and Biotechnology) at Cambridge. The project will use chemical techniques to assemble and functionalise the nanoparticles with ligands (peptides, nucleotides, small molecules) and cell biology techniques to characterise the nanoparticle properties and activities in mammalian cells.

Applicants should have a first degree or PhD in chemistry, materials science or in an area relevant to the project. The key duties and responsibilities will include but are not limited to: developing research objectives and conducting the research project, continually updating knowledge and understanding in the field, translating knowledge and advances the research activity; supporting research activities and communication through participation at group meetings/seminars; contributing to the supervision of junior researchers and PhD students and acting as a mentor to less experienced colleagues; writing up research work for publication; dissemination of research results by presentation at national and international meetings.

The successful candidate will have experience in nanomaterial preparation and biofunctionalisation, and organic synthesis with emphasis on click chemistry. Experience in the field of nanomaterials and drug delivery is desired but not essential. Some experience with cell-based work is desirable but not essential. Excellent writing and presentation skills are required, along with the ability to develop and drive research objectives. It is expected that the candidate will contribute substantially to the future direction of the project.

The funds for this post are available for 36 months. The salary range if appointed as a Research Associate is Grade 7 - £33,309-£40,927 per annum, and the salary range if appointed as Research Assistant is Grade 5 - £27,116-£31,406 annum with promotion to Research Associate on attainment of PhD if applicable.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Starting date: 01/11/2022 or as soon as possible after

The two departments hold Athena SWAN bronze awards, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. Appointment will be based on merit alone.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the position can be made to Prof Laura Itzhaki (lsi10@cam.ac.uk) or Prof Ljiljana Fruk (lf389@cam.ac.uk).

Please quote reference PL32743 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Department/Location

Department of Pharmacology, Department of Chemical Engineering and Biotechnology, Central Cambridge

Salary

£27,116-£40,927

Reference

PL32743

Category

Research

Published

15 August 2022

Closing date

25 September 2022

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