Research Assistant (Part Time, Fixed Term)

University of Cambridge
July 14, 2024
Contact:N/A
Offerd Salary:£29,605-£33,966
Location:N/A
Working address:N/A
Contract Type:Fixed-term: The fund
Working Time:Part time
Working type:N/A
Ref info:N/A
Research Assistant (Part Time, Fixed Term)

We wish to recruit a highly motivated Research Assistant to join the laboratory of Prof Rahul Roychoudhuri within the Division of Immunology at the Department of Pathology, University of Cambridge (https:// www. roychoudhurilab.org).

Despite the success of CAR T cell therapy in haematological malignancies, its application in solid tumours has faced significant challenges. Solid tumours often exhibit genetic and phenotypic heterogeneity, making it difficult to identify a single target antigen consistently expressed on all tumour cells. Moreover, solid tumours create an immunosuppressive microenvironment that inhibits the function and survival of CAR T cells. The complex extracellular matrix of solid tumours can also act as a physical barrier, preventing efficient homing and penetration of CAR T cells into the tumour mass. Furthermore, CAR T cells can become exhausted and lose their effector function over time, particularly in the context of chronic antigen exposure and the immunosuppressive tumour microenvironment. This research aims to enhance the persistence and long-term functionality of CAR T cells through genetic modifications of transferred cells based on a mechanistic understanding of CD8 T cell biology.

The successful applicant will join a large, friendly and collaborative team of researchers with access to cutting-edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site. The applicant will gain exposure to cutting-edge experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell barcoding and fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing. The applicant will also have the opportunity to utilise platforms for high-throughput CRISPR/Cas9-based mutagenesis screens recently developed in the laboratory. The applicant will benefit from the collaborative and collegial environment of the laboratory, the Department and the wider research community present in Cambridge. The project will also benefit from a collaboration with the groups of Prof Adrian Liston and Dr Tim Halim within Cambridge, bringing together leading scientific and technical expertise in cancer immunology/immunotherapy, immune regulation and inflammation biology. The ideal candidate will be motivated, independent and enthusiastic, and have a an undergraduate degree in immunology, cell biology, or a related field. Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable. Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable.

Key responsibilities:

  • Conducting research in the field of immunology and immunotherapy

  • Leading collaborations with other researchers within the group, and in other laboratories

  • Essential criteria:

  • Independent, motivated and highly organized individual, who is passionate about science and keen to support the day-to-day coordination of a collaborative team of scientists

  • Applicants must have a degree in Immunology, Molecular Biology, Cell Biology or a related discipline

  • Experience of mouse immunology, including working with experimental mice, tissue dissection and flow cytometry. Ability to learn and assimilate new techniques, and to train other researchers

  • Demonstrate core values of enthusiasm, openness and integrity.

  • Fixed-term: The funds for this post are available for 2 years in the first instance

    Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

    Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

    Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

    For more information about the work of the laboratory, visit: https:// roychoudhuri.path.cam.ac.uk Informal enquiries about the position can be made by email to [email protected]

    Please quote reference PK42257 on your application and in any correspondence about this vacancy.

    The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

    The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

    Department/Location

    Department of Pathology, Central Cambridge

    Salary

    £29,605-£33,966 pro rata

    Reference

    PK42257

    Category

    Research

    Published

    1 July 2024

    Closing date

    14 July 2024

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