Research Assistant (Fixed Term) (Mendez-Ferrer Lab)
We are seeking an enthusiastic full-time Research Assistant to join the group
of Prof Simon Mendez-Ferrer within the Haematology Department based on the
Cambridge Biomedical Campus
(https: // www. stemcells.cam.ac.uk/people/pi/mendez-ferrer). The Mendez-Ferrer
lab is focused on the regulation of the haematopoietic stem-cell niche in
health and disease. Blood stem cells reside in specialised niches that allow
them to self-renew, proliferate, differentiate and migrate according to the
organism's requirements. The group has demonstrated that the brain regulates a
peripheral stem cell niche in the bone marrow partly through sympathetic
innervation of mesenchymal stem cells that share a niche with haematopoietic
stem cells. Ageing is associated with an increased risk to develop myeloid
malignancies, such as myeloproliferative neoplasms (MPNs) and acute myeloid
leukaemia (AML). The group has shown that the remodelling of the bone marrow
microenvironment promotes myeloid cell expansion during premature or
physiological ageing. Indeed, damage to this niche regulation is required for
MPN progression. Neuroendocrine regulation of bone marrow stem cells by
adrenergic signals or by sex hormones could potentially offer novel
therapeutic approaches in MPN. Furthermore, AML cells co-opt energy sources
and antioxidant defence mechanisms from niche-forming mesenchymal stem cells
to survive chemotherapy, offering potential adjuvant therapies to decrease AML
The successful candidate should hold a degree in a biomedical field or
equivalent. Prior experience of laboratory-based research and working with
laboratory mice and human samples are essential. An understanding of
principles of cellular and molecular biology techniques (DNA; RNA and protein
extraction; RT, PCR, QPCR, flow cytometry, cell culture, Western Blot) would
The successful candidate will be expected to support the research team by
providing technical assistance in the research projects and recording data
from experiments. You will be expected to plan your own day-to-day research
activity, coordinating with other group members to avoid duplication or
conflict. You will be offered the possibility to develop your own research
project of interest, provided it is compatible with fulfilling other
responsibilities, which include a wide range of tasks to ensure the smooth
running of the laboratory, including ordering and maintaining laboratory
supplies, as well as maintaining and updating protocols and reagent databases.
The closing date for applications is 15 November 2021.
Interviews for the position will take place during week commencing 22 November
Informal enquiries directed to Prof Simon Mendez-Ferrer, email@example.com are
Fixed-term: The funds for this post are available until 31 May 2024 in the
Once an offer of employment has been accepted, the successful candidate will
be required to undergo a health assessment and a security check.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section
of the online application. If you upload any additional documents which have
not been requested, we will not be able to consider these as part of your
Please include details of your referees, including email address and phone
number, one of which must be your most recent line manager.
Please quote reference RB28436 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Department of Haematology
7 October 2021
15 November 2021