Research Assistant - Cancer Biobank (Fixed Term)
Applications are invited for a research assistant position within the Liquid
Biopsies and Cancer Diagnostics Group (https:// www. rosenfeldlab.org/) led by
Dr Nitzan Rosenfeld at the CRUK Cambridge Institute. The Rosenfeld lab
pioneers new approaches for non-invasive molecular diagnostics and analysis of
cancer genomes and evolution, using next-generation sequencing of cell-free
tumour DNA (ctDNA). We work with large collections of patient material from
different clinical studies (encompassing a variety of cancer types), which
we analyse by both genome-wide methods and targeted methods for sensitive
mutation detection. We aim to build novel tools for cancer diagnostics by
developing improved methods and demonstrating clinical utility.
We seek an individual to support the general running of the Rosenfeld
laboratory. The position will include a mix of laboratory based and
administrative work. Key duties include;
ensuring the integrity of the Rosenfeld lab's sample banks (thousands of
human samples including blood plasma, urine, cerebrospinal fluid, tissue,
DNA, sequencing libraries, etc).
initially there will be considerable time spent to reorganisation of the
group's extensive sample storage facilities.
maintenance of records documenting permissions for working on samples.
e.g. trial protocols and material transfer agreements (MTAs).
regular auditing of samples, records and database entries.
recording and ensuring that the group, and its individual members, follow
procedures enabling compliance with relevant legislation regarding Human
Tissue Act (2004).
supporting the lab's research efforts by carrying out routine molecular
biology techniques such as DNA extraction, digital PCR,
Tapestation/Bioanalyser, library preparation and hybrid capture.
helping group members with regular and bespoke laboratory procedures and
work with unscreened human samples (blood plasma, urine etc; as such the
candidate will need to demonstrate immunity to Hepatitis B or undertake
This is an exciting opportunity to join a multi-disciplinary, translational
research group and contribute to our efforts to establish ctDNA as a biomarker
for routine clinical use. Applicants should have a B.Sc. or M.Sc. degree in a
relevant scientific discipline. Excellent IT skills (including an advanced
working knowledge of Microsoft Excel) are required and ideally experience
working with complex databases and laboratory information management systems
(LIMS), or similar. Some working knowledge of the relevant legal and
regulatory requirements governing the ethical conduct of research using human
tissue samples (eg Human Tissue Act (2004), MHRA guidelines, GCLP) would
be an advantage, as would experience of working with human tissue samples or
other potentially infectious material, at containment level 2.
Experience of molecular biology techniques such as PCR and next-generation
sequencing would be an advantage. You must have demonstrable ability to work
to agreed protocols and standard operating procedures, have good
organisational skills and be able to work independently, as well as within a
team. Good communication skills will be key to coordinate projects with
clinical collaborators, bioinformaticians and other researchers in the group.
Informal enquiries may be made to Rosenfeld.LabAdmin@cruk.cam.ac.uk.
Fixed-term: The funds for this post are available for 18 months in the first
Once an offer of employment has been accepted, the successful candidate will
be required to undergo a security check.
We welcome applications from individuals who wish to be considered for part-
time working or other flexible working arrangements.
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Closing Date: 11th October 2021.
Please ensure that you upload a covering letter and CV in the Upload section
of the online application. The covering letter should outline how you match
the criteria for the post and why you are applying for this role. If you
upload any additional documents which have not been requested, we will not be
able to consider these as part of your application.
Please include details of your referees, including email address and phone
number, one of which must be your most recent line manager.
Please quote reference SW28148 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
Cancer Research UK Cambridge Institute
14 September 2021
11 October 2021