Research Assistant/Associate

University of Glassgow
January 29, 2023
Contact:N/A
Offerd Salary:£30,502 - £34,308
Location:N/A
Working address:N/A
Contract Type:fixed term until 30
Working Time:Full time
Working type:N/A
Ref info:N/A
Research Assistant/Associate

We are seeking to appoint a Research Assistant/Associate to make a leading contribution to the project: 'ROS via RET: a redox-regulated pathway to extend lifespan' supported by Wellcome. You will conduct, manage and publish research in the biology of ageing.

The laboratory has characterised the first site-specific ROS signalling pathway, which regulates animal lifespan: mitochondrial ROS produced via reverse electron transport (ROS-RET) at respiratory complex I.

The successful candidate will work towards fully characterising this new anti- ageing signalling pathway by addressing three aims: (i) identify proteins involved in the initiation, amplification and neutralisation of ROS-RET using both hypothesis and non-hypothesis approaches (e.g. proteomics), (ii) understand when and where ROS-RET needs to be activated to extend lifespan using state-of-the-art technology to edit the fly genome, and (iii) dissect the epigenetic and metabolic changes associated with ROS-RET signalling producing and analysing RNAseq and metabolomics data respectively.

The School contains a multi-disciplinary centre of excellence conducting fundamental and translational life science research underpinning health and food security. The School is one of eight Schools in the College of Medical, Veterinary and Life Sciences.

Job Purpose

To make a leading contribution to the project: 'ROS via RET: a redox-regulated pathway to extend lifespan' supported by Wellcome.

Specifically, the postholder will conduct, manage and publish research in the area of biology of ageing. Our laboratory has characterised the first site- specific ROS signalling pathway, which regulates animal lifespan: mitochondrial ROS produced via reverse electron transport (ROS-RET) at respiratory complex I. You will work towards fully characterising this new anti-ageing signalling pathway by addressing three aims: (i) identify proteins involved in the initiation, amplification and neutralisation of ROS- RET using both hypothesis and non-hypothesis approaches (e.g. proteomics), (ii) understand when and where ROS-RET needs to be activated to extend lifespan using state-of-the-art technology to edit the fly genome, and (iii) dissect the epigenetic and metabolic changes associated with ROS-RET signalling producing and analysing RNAseq and metabolomics data respectively.

Main Duties and Responsibilities

Perform the following activities in conjunction with and under the guidance of the Principal Investigator:

1. Plan and conduct assigned research individually or jointly in accordance with the project deliverables and Sanz Lab research strategy.

2. Document research output, including analysis and interpretation of all data, maintaining records and databases, drafting technical/progress reports and papers as appropriate.

3. Develop and enhance your research profile and reputation and that of the University of Glasgow, including contributing to international quality publications in high profile/quality refereed journals, enhancing the research impact in terms of economic/societal benefit, and gathering indicators of esteem.

4. Contribute to the presentation of work at international and national conferences, at internal and external seminars, colloquia and workshops to develop and enhance our research profile.

5. Contribute to the identification of potential funding sources and to assist in the development of proposals to secure funding from internal and external bodies to support future research.

6. Collaborate with colleagues and participate in team/group meetings/seminars/workshops across the Sanz Laboratory and broader community.

7. Contribute to the organisation, supervision, mentoring and training of undergraduate and/or postgraduate students and less experienced members of the project team to ensure their effective development.

8. Perform administrative tasks related to the activities of the research group, including Budgets/Expenditure.

9. Carry out modest Teaching activities (e.g. demonstrating) and associated admin as assigned by the Principal Investigator.

10. Keep up to date with current knowledge and recent advances in the field/discipline.

11. Engage in continuing professional development activities as appropriate.

12. Undertake any other duties of equivalent standing as assigned by the Director of Research Institute.

13. Contribute to the enhancement of the University's international profile in line with the University's Strategic Plan, Inspiring People Changing the World.

For appointment at grade 7:

14. Perform the above duties with a higher degree of independence, leadership and responsibility, particularly in relation to planning, funding, collaborating and publishing research, and mentoring colleagues.

15. Establish and sustain a track record of independent and joint published research to establish and maintain your expert reputation in the subject area.

16. Develop expertise in the research literature and environment, understand the research challenges associated with the project & subject area, & develop/implement a suitable research strategy.

Qualifications

Essential

A1 SCQF Level 10 (Honours degree) in a relevant subject or a cognate discipline, or equivalent.

A2 Specialist theoretical and practical knowledge in a research-related to Molecular Biology, Cell Biology or Genetics.

A3 A comprehensive and up-to-date knowledge in the biology of ageing, mitochondrial biology or or any related field of research.

For appointment at grade 7 :

A4 A Scottish Credit and Qualification Framework level 12 (PhD) or possess the equivalent in professional qualifications and experience, with personal development experience in a similar or related role(s).

A5 A track record of publications in any relevant field of study (e.g. biology of ageing, mitochondrial biology or redox biology).

A6 Specialist theoretical and practical knowledge in a research-related to Molecular Biology.

Desirable

B1 Specialist theoretical and practical knowledge in a research-related to Cell Biology and/or Bioinformatics. B2 Knowledge of analysing high-throughput data particularly RNAseq and metabolomics data.

Knowledge, Skills and Experience

Essential

C1 Molecular Biology techniques.

C2 Excellent communication skills (oral and written), including public presentations and ability to communicate complex data/concepts clearly and concisely.

C3 Extensive IT and data analysis/interpretation skills as appropriate.

For appointment at grade 7:

C4 Knowledge of project-specific technical models, equipment or techniques.

C5 Sufficient depth of relevant research experience, normally including sufficient postdoctoral experience in a related field, appropriate to an early career researcher.

Desirable

D1 Cellular Biology techniques (e.g. fluorescence microscopy, ELISA, flow cytometry).

D2 CRISPR-CAS9 technology in animals or cell culture.

Experience

Essential

E1 Sufficient relevant research experience (or equivalent) appropriate to an early career researcher.

E2 Experience in scientific writing.

For appointment at grade 7:

E3 A track record of presentation and publication of research results in quality journals/conferences.

E4 Experience in making a leading contribution in academic activities.

E5 Evidence of an emerging track record of publications in a relevant field.

Desirable

F1 Work experience in different laboratories or environments.

Terms and Conditions

Salary will be Grade 6/7, £30,502 - £34,308/£37,474 - £42,155 per annum.

This post is full time and fixed term until 30 April 2024.

As part of Team UofG you will be a member of a world changing, inclusive community, which values ambition, excellence, integrity and curiosity.

As a valued member of our team, you can expect:

1 A warm welcoming and engaging organisational culture, where your talents are developed and nurtured, and success is celebrated and shared.

2 An excellent employment package with generous terms and conditions including 41 days of leave for full time staff, pension - pensions handbook https: // www. gla.ac.uk/myglasgow/payandpensions/pensions/, benefits and discount packages.

3 A flexible approach to working.

4 A commitment to support your health and wellbeing, including a free 6-month UofG Sport membership for all new staff joining the University https: // www. gla.ac.uk/myglasgow/staff/healthwellbeing/.

We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community https: // www. gla.ac.uk/myglasgow/humanresources/equalitydiversity/.

We endorse the principles of Athena Swan https: // www. gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan/ and hold bronze, silver and gold awards across the University.

We are investing in our organisation, and we will invest in you too. Please visit our website https: // www. gla.ac.uk/explore/jobs/ for more information.

Informal Enquiries should be directed to Professor Alberto Sanz Montero, [email protected]

Vacancy Ref: 106311, Closing Date: 29 January 2023.

Vacancy Ref : 106311 Close Date : 29-Jan-2023 23:45

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